Heterocyclic Building Blocks-piperidine

Li, Jingjing published the artcileFe/HZSM-5 catalyzed liquefaction of cellulose assisted by glycerol, Safety of Piperidine-4-carboxamide, the publication is Catalysis Communications (2021), 106268, database is CAplus.

Fe/HZSM-5 catalyst was prepared by the impregnation method and employed for the liquefaction of cellulose at 350°C for 30 min. Iron changed the surface acidity of HZSM-5 and provided stronger acid sites. Fe/HZSM-5 improved the yield of bio-oil, and the coke formation was inhibited compared to HZSM-5 alone. The presence of glycerol and Fe/HZSM-5 promoted both the hydrodeoxygenation (HDO) and aromatization reactions. Ketones yields decreased from 29% to 7%, and the content of aromatics and furans increased significantly. The possible hydrogen supply mechanism of glycerol and the route of cellulose liquefaction were proposed.

Catalysis Communications published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Safety of Piperidine-4-carboxamide.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Diao, Zeng-Hui published the artcileInsights on the nitrate reduction and norfloxacin oxidation over a novel nanoscale zero valent iron particle: Reactivity, products, and mechanism, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Science of the Total Environment (2019), 541-549, database is CAplus and MEDLINE.

Herein, the application of a novel acid mine drainage-based nanoscale zero valent iron (AMD-based nZVI) for the remediation of nitrate and norfloxacin (NOR) was studied. Exptl. results indicated that the catalytic reactivity of AMD-based nZVI toward nitrate reduction was superior to that of iron salt-based nanoscale zero valent iron (Iron salt-based nZVI). The presence of ultrasound irradiation could significantly enhance the reactivity toward both the nitrate reduction and NOR oxidation processes. The optimal efficiencies of nitrate and NOR by AMD-based nZVI/US process could be kept 96 and 94% within 120 min, resp. Ammonia was identified as a major product in nitrate reduction process, while three oxidation products were observed in NOR degradation process. Both reduction reaction of nitrate from AMD-based nZVI and oxidation reaction of NOR from US-assisted Fenton system might be involved in AMD-based nZVI/US process. The AMD-based nZVI/US process showed a better performance on the removal of NOR compared with that of nitrate. The findings of the present work could be as a guide and show that AMD-based nZVI/US process is feasible for the remediation of both nitrate and NOR in real wastewater.

Science of the Total Environment published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Nicolaou, K. C. published the artcileSynthesis and Biological Investigation of Δ¹²-Prostaglandin J₃ (Δ¹²-PGJ₃) Analogues and Related Compounds, Synthetic Route of 219543-09-6, the publication is Journal of the American Chemical Society (2016), 138(20), 6550-6560, database is CAplus and MEDLINE.

A series of Δ¹²-prostaglandin J₃ (Δ¹²-PGJ₃) analogs and derivatives were synthesized employing an array of synthetic strategies developed specifically to render them readily available for biol. investigations. The synthesized compounds were evaluated for their cytotoxicity against a number of cancer cell lines, revealing nanomolar potencies for a number of them against certain cancer cell lines. Four analogs (I–IV) demonstrated inhibition of nuclear export through a covalent addition at Cys528 of the export receptor Crm1. One of these compounds (i.e., II) is currently under evaluation as a potential drug candidate for the treatment of certain types of cancer. These studies culminated in useful and path-pointing structure-activity relationships (SARs) that provide guidance for further improvements in the biol./pharmacol. profiles of compounds within this class.

Journal of the American Chemical Society published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, Synthetic Route of 219543-09-6.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Wohl, A. published the artcileArecolone and N-methyl-ω-amina-β-pipecoline, Recommanded Product: (1-Methylpiperidin-3-yl)methanamine, the publication is Justus Liebigs Annalen der Chemie (1924), 139-49, database is CAplus.

Condensation of (EtO)₂CHCH₂CH₂NH₂ and HCHO gives an anhydro-base, [CH₂:NCH₂CH₂CH(OEt)₂]_n, oil which decomposes on distilling in vacuo and reduces Fehling solution and NH₄OH-AgNO₃. A modification of Blaise and Maire’s method for CH₂:CHAc (C. A. 2, 1824) is given, the yields being 25-35%. The residue, treated with AcCl, gives the compound, C₉H₁₄O₅, m. 85°. CH₂: CHAc does not appear to condense with (EtO)₂CHCH₂NH₂ to give a definite compound With (EtO)₂CHCH₂CH₂NHMe, there results the compound, (EtO)₂CHCH₂CH₂NMeCH₂CH₂Ac, light yellow oil, which cannot be distd, in vacuum but with concentrated HCl in a cooling mixture it yields 40-60% of the HCl salt, m. 204°, of arecolone (N-methyl-Δ³-tetrahydropyridine β-Me ketone), light yellow oil, b_0.01 80-2°, reduces acid KMnO₄ in the cold. HBr salt, m. 223°. Semicarbazone, m. 219° (decomposition); HCl salt, m. 233°. Arecaidine aldehyde oxime, m. 130°. Reduction with Na-Hg gives 50% of N-methyl-ω-amino-β-pipecoline, b₁₂ 116-8°; Bz derivative, m. 161-2°.

Justus Liebigs Annalen der Chemie published new progress about 14613-37-7. 14613-37-7 belongs to piperidines, auxiliary class Piperidine,Amine, name is (1-Methylpiperidin-3-yl)methanamine, and the molecular formula is C18H35NO, Recommanded Product: (1-Methylpiperidin-3-yl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Qiu, Joseph C. published the artcileSelective Oxoammonium Salt Oxidations of Alcohols to Aldehydes and Aldehydes to Carboxylic Acids [Erratum to document cited in CA156:073637], HPLC of Formula: 219543-09-6, the publication is Organic Letters (2012), 14(15), 4034, database is CAplus.

On page S3 of the Supporting Information, describing the General Procedure for the Oxidation of Alcs. to Carboxylic Acids, the oxidant itself and the amount of oxidant were omitted; the correct version of the Supporting Information is given.

Organic Letters published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, HPLC of Formula: 219543-09-6.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Qiu, Joseph C. published the artcileSelective Oxoammonium Salt Oxidations of Alcohols to Aldehydes and Aldehydes to Carboxylic Acids, Recommanded Product: 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, the publication is Organic Letters (2012), 14(1), 350-353, database is CAplus and MEDLINE.

The oxidation of alcs. to aldehydes using stoichiometric 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (I) in CH₂Cl₂ at room temperature is a highly selective process favoring reaction at the carbinol center best able to accommodate a pos. charge. The oxidation of aldehydes to carboxylic acids by I in wet acetonitrile is also selective; the rate of the process correlates with the concentration of aldehyde hydrate. A convenient and high yield method for oxidation of alcs. directly to carboxylic acids has been developed.

Organic Letters published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, Recommanded Product: 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Dalacroix, A. published the artcileUse of experience plans associated with direct methods for optimization in chemometry, Name: 1-Ethylpiperidin-3-ol, the publication is Analusis (1996), 24(1), M22-M25, database is CAplus.

Experience plans are discussed in connection with chemometry for statistical optimization of anal. methods and reaction processes, including methods for colorimetric dosing of ergotamine, the process of chlorination of ethyl-1-hydroxy-3-piperidine, generally spectrophotometric methods of anal., the process of urethane prepolymer synthesis, and the process of n-thymol synthesis by m-cresol alkylation.

Analusis published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Name: 1-Ethylpiperidin-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Loman, Jacob J. published the artcileOxidative Cleavage of Silyl Ethers by an Oxoammonium Salt, Application In Synthesis of 219543-09-6, the publication is Synlett (2016), 27(16), 2372-2377, database is CAplus.

A method for the oxidative cleavage of silyl ethers to their corresponding carbonyl species mediated by an oxoammonium salt is described. The resulting aldehydes and ketones are obtained under mild reaction conditions with no observed over oxidation For robust substrates, heating to reflux temperatures significantly reduces the reaction time.

Synlett published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, Application In Synthesis of 219543-09-6.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Pasqualetto, Gaia published the artcileLigand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin, COA of Formula: C6H12N2O, the publication is European Journal of Medicinal Chemistry (2021), 113841, database is CAplus and MEDLINE.

Inherited blinding diseases retinitis pigmentosa (RP) and a subset of Leber’s congenital amaurosis (LCA) are caused by the misfolding and mistrafficking of rhodopsin mols., which aggregate and accumulate in the endoplasmic reticulum (ER), leading to photoreceptor cell death. One potential therapeutic strategy to prevent the loss of photoreceptors in these conditions is to identify opsin-binding compounds that act as chem. chaperones for opsin, aiding its proper folding and trafficking to the outer cell membrane. Aiming to identify novel compounds with such effect, a rational ligand-based approach was applied to the structure of the visual pigment chromophore, 11-cis-retinal, and its locked analog 11-cis-6mr-retinal. Following mol. docking studies on the main chromophore binding site of rhodopsin, 49 novel compounds, e.g., I, were synthesized according to optimized one-to seven-step synthetic routes. These agents were evaluated for their ability to compete for the chromophore binding site of opsin, and their capacity to increase the trafficking of the P23H opsin mutant from the ER to the cell membrane. Different new mols. displayed an effect in at least one assay, acting either as chem. chaperones or as stabilizers of the 9-cis-retinal-rhodopsin complex. These compounds could provide the basis to develop novel therapeutics for RP and LCA.

European Journal of Medicinal Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, COA of Formula: C6H12N2O.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Hassannia, Ali published the artcileA simple and efficient synthesis of 1,4- and 1,5-dioxepan-2-one, Application of 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, the publication is Letters in Organic Chemistry (2009), 6(6), 478-480, database is CAplus.

A novel synthesis of 1,4- and 1,5-dioxepan-2-one lactones was achieved through the regioselective oxidation of 3-(2-hydroxyethoxy)propan-1-ol. Under basic conditions, when 3-(2-hydroxyethoxy)propan-1-ol was oxidized using oxoammonium salts, a quant. oxidative esterification was observed, resulting in a regioselective lactone ring closure. This oxidation was tailored to afford 1,4-dioxepan-2-one in very good yield.

Letters in Organic Chemistry published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, Application of 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem