Heterocyclic Building Blocks-piperidine

1312412-87-5, tert-Butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0148] Method H-Step d: Tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine- 5(4H)-carboxylate [0149] A mixture of tert-butyl 3-bromo-2,4-dioxopiperidine-l-carboxylate (292 mg, 1 mmol), thiourea (76 mg, 1 mmol) and NaHCC>3 (84 mg, 1 mmol) in ethanol (4 mL) was heated at 80C for 2 hours. The reaction mixture was then cooled to room temperature and the solids were filtered off. The filtrate was evaporated in vacuo to give a residue that was crystallized from EtOH. The white crystals thus obtained were filtered off and dried to yield 200 mg (74.3% for two steps). *H NMR (400 MHz, DMSO-i5) delta 8.08 (s, 2H), 3.89 (t, J Hz, 2H), 2.75 (t, / = 6.4 Hz, 2H), 1.44 (s, 9H)., 1312412-87-5

1312412-87-5 tert-Butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate 69919790, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
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71233-25-5,71233-25-5, 1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Na (4.24 g, 184 mmol, 4.37 mL, 2.50 eq) in EtOH (400 mL) was added 1 -tert- butyl 4-ethyl 3-oxopiperidine-l,4-dicarboxylate (20.0 g, 73.7 mmol, 1.00 eq) and acetic acid methanimidamide (11.5 g, 111 mmol, 1.50 eq) under N2. The mixture was stirred at 70 ¡ãC for 5 hours. The reaction mixture was adjusted to pH 7 with HCl (IN), extracted with DCM (3 x 200 mL), washed with brine (1 chi 400 mL), dried over Na2S04, filtered and concentrated under vacuum to give tert-butyl 4-hydroxy-6,8-dihydro-5H-pyrido [3,4-d]pyrimidine-7-carboxylate (16.0 g, 63.7 mmol, 86.4 percent yield) as a brown solid. ESI MS m/z 274.0 [M+H]+.

71233-25-5 1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate 15852989, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
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147539-41-1, tert-Butyl 4-(methylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 191a4-Methylamino-piperidine-l-carboxylic acid tert-butyl ester (500 mg, 1.87 mmol) was suspended in 10 ml of 1,2-dichloroethane. Tetrahydro-pyran-4-one (0.17 ml, 1.87 mmol) was added and the reaction mixture was stirred at room temperature for 30 min. Sodium triacetoxyborohydride (593 mg, 2.80 mol) was added and the reaction mixture was stirred for 18 h. The reaction mixture was diluted with dichloromethane and washed with an aqueous saturated sodium bicarbonate solution.The organic phase was dried over sodium sulfate and concentrated under vacuum. The crude product was purified by flash chromatography (Isolute silica gel cartridge 1Og; eluent: dichloromethane/methanol=94/6percent). 240 mg (0.80 mmol) of the desired compound were obtained., 147539-41-1

As the paragraph descriping shows that 147539-41-1 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; EBEL, Heiner; FRATTINI, Sara; GIOVANNINI, Riccardo; HOENKE, Christoph; TRIESELMANN, Thomas; TIELMANN, Patrick; SCHEUERER, Stefan; HOBBIE, Silke (Marie Katrin); WO2010/70032; (2010); A1;,
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79421-45-7, 1-(4-Nitrophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of the yellowish solid (0.90 g, 4.05 mmol) and palladium on carbon (Pd(C)) (10%, 120 mg) in methanol (MeOH) (20 mL) containing aqueous 6N HCl (0.20 mL) was hydrogenated under a balloon of H2 overnight. It was then filtered through celite. The filtrate was concentrated in vacuo to give 1-(4-aminophenyl)piperidin-4-ol as a solid (0.841 g)., 79421-45-7

As the paragraph descriping shows that 79421-45-7 is playing an increasingly important role.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; US2009/54425; (2009); A1;,
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22065-85-6, 1-Benzylpiperidine-4-carbaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-3) 1-Benzyl-4-[(5,6-diethoxy-1-indanon)-2-ylidene]methylpiperidine To a solution of 24.1 g of 5,6-diethoxy-1-indanone in 70 ml of THF was added 26.7 g of 1-benzyl-4-formylpiperidine in 100 ml of THF, followed by addition of a solution of 23.2 g of sodium methoxide (28% methanol solution) in 30 ml of THF under ice-cooling. After stirring for 2 hours as it was, the mixture was poured onto ice water, and the precipitated solid was collected by filtration and dried. The product was recrystallized from ethyl acetate-ethanol, to give 39.6 g (89%) of the title compound as white crystals., 22065-85-6

The synthetic route of 22065-85-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eisai Co., Ltd.; EP1468684; (2004); A1;,
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187834-88-4, 1-Boc-isonipecoticacidhydrazide is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of Compound [CCCX1H] (600 mg, 2.47 mmol), Compound [CCCXTV] (291 mg, 2.47 mmol), and sodium methoxide (266 mg, 25 wt% solution in methanol) in 2-ethoxyethanol (6 mL) was heated at 125 C for 16 h. The reaction mixture was partitioned between EtOAc and saturate aqueous ammonium chloride solution. The aqueous layer was extracted with additional EtOAc. The combined organic layer was dried over Na2SO4, filtered, and concentrated. The crude material was purified by ISCO to obtain Compound [CCCXVJ as a colorless oil (73.3 mg, 9%). 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.57 (s, 9 H) 1.77 – 1.95 (m, 2 H) 2.09 (d, J=2.44 Hz, 2 H) 2.62 (s, 3 H) 2.89 – 3.01 (m, 2 H) 3.06 (br. s., 1 H) 3.98 – 4.51 (m, 2 H) 7.22 (d, J=4.59 Hz, 2 H) 8.50 (d, >;4.93 Hz, 2 H) 9.07 (br. s., 1 H).

187834-88-4, 187834-88-4 1-Boc-isonipecoticacidhydrazide 22713165, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP &; DOHME CORP.; BANYU PHARMACEUTICAL CO., LTD.; FAN, Weiming; HAXELL, Thomas, F. N.; JENKS, Matthew, G.; KAWANISHI, Nobuhiko; LEE, Shuliang; LIU, Hao; MALASKA, Michael, J.; MOORE, Joseph, A., III; OGINO, Yoshio; ONOZAKI, Yu; PANDI, Bharathi; PEEL, Michael, R.; SAKAMOTO, Toshihiro; SIU, Tony; WO2010/104933; (2010); A1;,
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Piperidine | C5H11N – PubChem

143900-44-1, (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (S)-1 -Boc-3-hydroxypiperidine (10.0 g, 49.7 mmol) and triethylamine (7.82 mL, 54.7 mmol in DCM (60 mL) under a nitrogen atmosphere, cooled at 0 ¡ãC, was added dropwise methanesulfonyl chloride (4.23 mL, 54.7 mmol). The mixture stirred for 1 h, diluted with water (60 mL) before being passed through a hydrophobic frit. The organic layer was concentrated under reduced pressure to afford fe/ -butyl (3S)-3-methylsulfonyloxypiperidine-1 -carboxylate (13.9 g, 49.7 mmol, 100percent yield) as a colourless solid. H-NMR (400 MHz, DMSO-c/6): delta (ppm) 4.76-4.71 (m, 1 H, CH), 3.69-3.66 (m 1 H), 3.65-3.60 (m, 1 H), 3.49-3.43 (m, 1 H), 3.37-3.31 (m, 1 H), 3.07 (s, 3H, CH3), 2.02-1 .96 (m, 1 H), 1 .94-1 .91 (m, 1 H), 1 .87- 1 .80 (m, 1 H), 1 .59-1 .53, 1 .48-1 .45 (m, 9H), 143900-44-1

The synthetic route of 143900-44-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REDX PHARMA LIMITED; ARMER, Richard; BINGHAM, Matilda; MORRISON, Angus; CARSWELL, Emma; ELUSTONDO, Fred; WALKER, Rolf; GUISOT, Nicolas; LUCAS, Catherine; WO2014/188173; (2014); A1;,
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106-52-5, 1-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of N-methyl piperidinol (0.22 g, 1.96 mmol) and sodium hydroxide (79 mg, 1.96 mmol) in benzene (10 mL) was heated to reflux for 2 hours with stirring under nitrogen atmosphere and then cooled to 25 C. followed by the addition of compound 133 (0.25 g, 0.65 mmol) at same temperature. The mixture was heated to reflux for 6 hours, concentrated under vacuum and diluted with water (10 mL). The precipitated solid was filtered and purified by column chromatography (5-10% MeOH-CHCl3) to afford the title compound E26 as a pale yellow solid (0.16 g, 53%). HPLC: Hichrom RPB (250*4.6 mm) 5 microns [solvent A=0.01 M KH2PO4 (pH 7.0); solvent B=CH3CN], Gradient elution program: T/% B=0/60, 10/60, 25/80, 40/80, 45/60, 50/60; 270 nm, Rt 35.21 min, 98.09% purity; MS (CI): m/z 461 (M+H, 50), 364 (100).

106-52-5, As the paragraph descriping shows that 106-52-5 is playing an increasingly important role.

Reference£º
Patent; Timmer, Richard T.; Alexander, Christopher W.; Pillarisetti, Sivaram; Saxena, Uday; Yeleswarapu, Koteswar Rao; Pal, Manojit; Reddy, Jangalgar Tirupathy; Krishna Reddy, Velagala Venkata Rama Murali; Sridevi, Bhatlapenumarthy Sesha; Kumar, Potlapally Rajender; Reddy, Gaddam Om; US2004/209881; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.159635-49-1,tert-Butyl 4-methylenepiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Synthesis of tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate; Dry DME (8.0 L) and tert-butyl 4-methylenepiperidine-1-carboxylate (800 g, 4.06 mol) were charged to a reactor. Zinc-copper couple (800 g; CAS No.53801-63-1, Alfa-Aesar) was charged to the reactor, and the mixture was warmed to 34¡ã C. Trichloroacetyl chloride (1448 g, 8.0 mol, 888 mL) was added dropwise under a nitrogen atmosphere to the stirred suspension in the following manner: 80 mL of trichloroacetyl chloride was added. After 10 min, an exotherm elevated the reaction temperature to 39¡ã C. Dropwise addition of the remaining trichloroacetyl chloride was resumed immediately at a rate to maintain a temperature between 40-44¡ã C. using a 25¡ã C. jacket. After the addition was complete, the reaction was stirred at 40¡ã C. for 15 min. Cyclohexane (10 L) was added to the mixture. The mixture was filtered through a pad of celite, washing with cyclohexane (2 L). The filtrate was concentrated to approximately 3 L and then was diluted with MTBE (3 L) and cyclohexane (2 L) and filtered through a pad of magnesol (1 kg), washing with 1:1 cyclohexane/MTBE (3 L). The filtrate was washed with saturated potassium bicarbonate (3 L) and brine (2 L). The organic layer was filtered through a pad of silica gel (300 g) with a pad of magnesol (200 g) on top. The filtrated was concentrated to yield the title compound as an orange solid (1123 g, 91percent). 1H NMR (400 MHz, CDCl3) delta ppm 4.05-4.13 (m, 2H), 3.08 (s, 2H), 2.80-2.88 (m, 2H), 1.88-1.97 (m, 2H), 1.71-1.78 (m, 2H), 1.46 (s, 9H). m/z 252, 254 (MH+ minus t-Bu)., 159635-49-1

159635-49-1 tert-Butyl 4-methylenepiperidine-1-carboxylate 2756808, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US2010/113465; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

479630-08-5, 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 5 (15 g, 45 mmol) was dissolved in anhydrous ethanol (400 mL) with compound 6 (9.45 g, 49.5 mmol), followed by addition of trifluoroacetic acid (20 mL) and heating at 80 C for 12 hours. Cool to room temperature and spin the solvent. The reaction mixture was diluted with water (100 mL), extracted with 1 M NaOH, and extracted with ethyl acetate (3×200 mL). The extract was dried over anhydrous sodium sulfate, filtered and dried with methanol: dichloromethane = 1:20 Compound 7 (13. 82 g, 72%) was isolated.

479630-08-5, As the paragraph descriping shows that 479630-08-5 is playing an increasingly important role.

Reference£º
Patent; HU, XIANMING; HONG, XUECHUAN; WANG, HONGBO; ZHU, XI; DING, MINGMIN; L, GUANGYAO; ZHANG, JIANQIAO; WEN, MENG; QU, CHUNRONG; ZHU, JINMEI; (14 pag.)CN104292233; (2016); B;,
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Piperidine | C5H11N – PubChem