Heterocyclic Building Blocks-piperidine

1016258-66-4, 1-tert-Butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To an ice-cold solution of O1-tert-butyl O4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (0.4 g, 1.41 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4 M, 5 mL) solution. The resulting mixture was stirred at rt for 30 minutes. After completion of reaction (by TLC), solvent was evaporated to obtain the product as a solid (0.28 g). MS: 183.27 [M+H]+.

1016258-66-4, The synthetic route of 1016258-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOTA EUROPE LTD.; US2012/88750; (2012); A1;,
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58333-75-8, 4-(2-Methoxyphenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 26 mmol 4-(2-methoxyphenyl)-piperidine (Maybridge) in 100 ml dry DICHLOROMETHANE were added 28.6 mmol triethylamine and 78 mmol ETHYLCHLOROFONNATE at 0 The solution was stirred at room temperature overnight, washed twice with 0.5 M HC1 (125 ml) then dried over MGS04 and evaporated. The product was sufficiently pure to be used in the following steps.

58333-75-8, 58333-75-8 4-(2-Methoxyphenyl)piperidine 544738, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; H. LUNDBECK A/S; WO2004/87155; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.236406-39-6,8-Boc-2,8-Diazaspiro[4.5]decane,as a common compound, the synthetic route is as follows.

General procedure: To a stirring solution of tert-butyl piperazine-1-carboxylate 5(3 mmol) or tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate 8or in CH3CN (50 mL) was added 1-bromopropan-2-one or but-3-en-2-one (4 mmol) and K2CO3 (5 mmol) at room temperature.The mixturewas stirred for 3e4 h at room temperature and filtered.The filtrate was diluted by H2O (250 mL) and extracted by DCM(100 mL 3). The combined organic layer was washed by brine,dried over anhydrous MgSO4, filtered, and concentrated. The residuewas purified over silica gel column (DCM: MeOH 40: 1) toyield oils compounds 6a-b or 9a-b (yield, 52%e61%)., 236406-39-6

236406-39-6 8-Boc-2,8-Diazaspiro[4.5]decane 23282900, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Apeng; Lv, Kai; Tao, Zeyu; Gu, Jian; Fu, Lei; Liu, Mingliang; Wan, Baojie; Franzblau, Scott G.; Ma, Chao; Ma, Xican; Han, Bing; Wang, Aoyu; Xu, Shijie; Lu, Yu; European Journal of Medicinal Chemistry; vol. 181; (2019);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39945-51-2,Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Imidazole (3.00 g, 44.0 mmol) and tert-butyldimethylsilyl chloride (6.63 g, 44.0 mmol) were added to 1-(benzyloxycarbonyl)piperidin-3-yl methanol (9.15 g, 36.7 mmol) in N,N-dimethylformamide (40 mL). The solution was stirred at room temperature for 6 hours. Subsequently, water was added and the mixture was extracted with ethyl acetate. The extract was washed with brine and was dried over magnesium sulfate, followed by evaporation of the solvent. Purification of the residue by silica gel column chromatography (hexane: ethyl acetate = 20:1 -> 5:1) gave 13.2 g (99%) of the desired compound as a colorless oil. 1H NMR (400 MHz, CDCl3) delta 0.02 (6H, s), 0.88 (9H, s), 1.11-1.25 (1H, m), 1. 40-1. 53 (1H, m), 1. 61-1.71 (2H, m), 1. 72-1. 80 (1H, m), 2.54-2.66 (1H, m), 2.79 (1H, td, J = 11. 6, 3.1 Hz), 3.34-3.51 (2H, m), 3.99-4.09 (1H, m), 4.12-4.19 (1H, m), 5.12 (2H, s), 7.29-7.39 (5H, m)., 39945-51-2

39945-51-2 Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate 2776577, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; KYORIN PHARMACEUTICAL CO., LTD.; EP1780210; (2007); A1;,
Piperidine – Wikipedia
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134441-61-5, (R)-N-Boc-Piperidine-2-methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The (2R)-piperidin-2-ylmethanol used as starting material was prepared as follows: Trifluoroacetic acid (3 ml) was carefully added to a stirring solution of tert-butyl (2R)-2- (hydroxymethyl)piperidine-l-carboxylate (1.15 g, obtained as described in Tetrahedron, 58 (2002), 1343 – 1354) in DCM (3 ml) and stirred at room temperature for 1 hour. Volatiles were removed in vacuo and the oil thus obtained dissolved in methanol (60 ml), and neutralized by addition of MP-Carbonate resin (polymer supported carbonate reagent ex. Argonaut Technologies Inc.) (approximately 1 g) whilst stirring at room temperature for 2 hours. The resin was filtered, washed with methanol (3 x 30 ml) and the filtrate concentrated. The resulting oil was dissolved in DCM (30 ml) and dried (MgSO4) before filtration and solvent removal to afford a grey oil (615 mg, 100%); NMR spectrum 1.44 – 1.51 (m, 2H), 1.61 (m, IH), 1.70 – 1.78 (m, 3H), 2.84 (m, IH), 3.03 (m, IH), 3.21 (d, IH), 3.49 (m, IH), 3.57 (dd, IH), 5.01 (bs, IH), 7.65 (bs, IH): Mass spectrum M+ 116., 134441-61-5

134441-61-5 (R)-N-Boc-Piperidine-2-methanol 6933953, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/92574; (2006); A1;,
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352673-16-6, 1-(2-Chlorobenzoyl)piperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of1-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)piperidine-4-carboxylic acid(900.00 mg, 2.71 mmol, 1.05eq) and HOBt (488.23 mg, 3.61 mmol, 1.40eq) in DCM (100.00 mL) was added EDCI (692.68 mg, 3.61 mmol, 1.40eq) . The reaction mixture was stirred for 15 min, at which time a solution of(3S)-tert-butyl 3-amino-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy) pentanoate(911.00 mg, 2.58 mmol, 1.00eq) and NMM (783.19 mg, 7.74 mmol, 851.29 uL, 3.00eq) in DCM (100.00 mL) was added and then the mixture was stirred for an additional 60 h at 25 C . The solution was diluted with DCM (100 mL) and washed with saturated aqueous sodium hydrogen carbonate (2 * 50 mL), saturated aqueous sodium chloride (1*100 mL), dried (MgSO4) and concentrated under reduced pressure. The residue was purified by flash silica gel chromatography (ISCO; 12 g SepaFlash Silica Flash Column, Eluent of 0~30%EtOAc/Petroleum ether gradient 36 mL/min) to give(3S)-tert-butyl 3-(1-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)piperidine- 4-carboxamido)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoate(16)(1.24 g, 1.71 mmol, 66% yield) as a yellow oil., 352673-16-6

352673-16-6 1-(2-Chlorobenzoyl)piperidine-4-carboxylic acid 778084, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Mou, Jianfeng; Wu, Songliang; Luo, Zhi; Guo, Fengying; He, Haiying; Wang, Jianhua; Lin, Fusen; Guo, Fengxun; Sun, Jianping; Shen, Liang; Zeng, Minggao; Wang, Chuan; Xu, Deming; Gu, Zhengxian; Tian, Xin; Zhang, Aiming; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Li, Jian; Chen, Shuhui; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1874 – 1878;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4876-59-9,4-(Dimethylamino)piperidine dihydrochloride,as a common compound, the synthetic route is as follows.

Dimethyl-piperidin-4-yl-amine dihydrochloride (Aldrich, 2.0 g, 9.95 mmol) and 4-fluoro-nitrobenzene (Aldrich, 2.5 g, 17.7 mmol) were added to methanol (30 mL). The mixture was heated to 90 C. and stirred for 3.5 hours. The mixture was treated with 1 N HCl to pH=1 and then extracted with diethyl ether (2*10 mL). The aqueous layer was treated with saturated sodium carbonate to pH=10 and then extracted with methylene chloride (2*20 mL). The organic layer was dried with sodium sulfate and the solvent was removed to give the desired product. 1.25 g, 50%. MS (m+H)+: 250.

4876-59-9, 4876-59-9 4-(Dimethylamino)piperidine dihydrochloride 22591440, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Ding, Qingjie; Jiang, Nan; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; US2005/239843; (2005); A1;,
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Piperidine | C5H11N – PubChem

5382-16-1, 4-Piperidinol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(d) A solution containing 4-piperidinol (5 g) and triethylamine (7 ml) in dichloromethane (50 ml) was treated with benzyl chloroformate (7.5 ml), added dropwise, and the resulting mixture was allowed to stand for 2 hours. The mixture was diluted with dichloromethane (50 ml) and washed with water (2*50 ml) and with saturated brine (50 ml). The organic solution was dried (MgSO4) and concentrated. The residue was purified by column chromatography, eluding with ether/hexane (50%, then 75%) followed by ether, to give 1-(benzyloxycarbonyl)piperidin-4-ol (7.5 g) as a colourless oil; NMR Spectrum 1.2-1.4 (2H, m); 1.6-1.8 (2H, m); 3.0-3.2 (2H, m); 3.6-3.8 (3H, m); 4.7 (1H, d); 5.05 (2H, s); 7.3-7.4 (5H, m).

5382-16-1, As the paragraph descriping shows that 5382-16-1 is playing an increasingly important role.

Reference£º
Patent; Zeneca Limited; US5612373; (1997); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.614730-97-1,1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.

614730-97-1, Step B The product from Step A (1.44 g, 6.17 mmol) was dissolved in 6 ml of pyridine and the solution was cooled to 0C. p-Toluenesulfonyl chloride (1.29 g, 6.79 mmol) was added and the mixture was stirred at room temperature for 4 hours. The reaction mixture was diluted with dichloromethane (250 mL) and washed with water (50 mL). The organic phase was dried over Na2SO4, filtered and the solvent was removed. The residue was purified using a Biotage flash chromatography system (ethyl acetate/n-heptane: 20 to 50%) to give a yellowish oil (2.2 g, 92%). 1H-NMR (400 MHz, CDCl3): delta = 7.79 (d, 2H), 7.36 (d, 2H), 3.96 (brs, 2H), 3.03 (m, 2H), 2.46 (s, 3H), 1.80 (m, 2H), 1.63-1.49 (m, 4H), 1.47 (s, 9H)

614730-97-1 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine 22248400, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; AC Immune S.A.; EP2377860; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

503614-92-4, 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

503614-92-4, 12.5 g (27.1 mmol) of substance of formula 11c obtained in example 10 is suspended in DMA, then under argon atmosphere 8.0 g (49.3 mmol) of carbonyldiimidazole (CDI) is added, and the mixture is heated to 60 C, and it is maintained at this temperature for 1 hour. Then 18.8 mL (13.7 g, 136 mmol) of triethylamine and 6.25 g (81 mmol) of ammonium acetate are added to the mixture. The stirring is continued for 1 hour. Water is added to the mixture and the suspension is slowly cooled to 20 C. The precipitated substance is filtered off and washed. After drying 11.36 g (24.7 mmol, 91%) of off-white substance is obtained. Mp.: 236-238 C.

The synthetic route of 503614-92-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EGIS GYOGYSZERGYAR ZRT.; MRAVIK, Andras; NAGY, Tamas; FARAGO, Janos; VOLK, Balazs; LUKACS, Gyula; NEMETH, Gabor; CZOBORNE HATVARI, Ilona; SLEGEL, Peter; CSONKA-KIS, Gy?z?; KORMANY, Robert; (39 pag.)WO2016/20711; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem