Heterocyclic Building Blocks-piperidine

51304-64-4, 4-Hydrazinyl-1-methylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,51304-64-4

Example 6 Trans-6-[2-(4-methoxyphenyl)ethenyl]-2-(1-methyl-4-piperidinyl)phthalazin-1(2H)-one 1-Methyl-4-hydrazinopiperidine (41.2 gm) was dissolved in 1000 ml of ethanol. To this was added 90 gm trans-5-[2-(4-methoxyphenyl)ethenyl]-3-hydroxyphthalide (refer to U.S. patent 4,665,181). The resulting mixture was refluxed for 5 hours, then concentrated to dryness and the product taken up in 2000 ml of 2.5 normal HCl and extracted three times with 700 ml ethyl acetate. The product was basified, extracted into chloroform, and concentrated to dryness. The product was dissolved in isopropanol, acidified with HCl, heated to reflux, charcoaled and allowed to cool and crystallize. After three more crystallizations 3.7 gm of pure material was obtained melting at 297 to 298C.

51304-64-4 4-Hydrazinyl-1-methylpiperidine 10920535, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; FISONS CORPORATION; EP309765; (1990); A3;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39945-51-2,Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 8 Synthesis of 3-formyl-piperidine-1-carboxylic acid benzyl ester (9) To a stirring, 0 C. solution of 0.303 g (1.20 mmol) of 3-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester (8) in CH2Cl2 (4.0 mL) was added 0.630g (1.44 mmol) of Dess-Martin periodinane, and the solution was stirred under N2. When the reaction was complete by TLC (about 30 min.), the reaction was concentrated, and then Et2O was added. After standing for about 15 min., the reaction was filtered through Celite wet with Et2O, rinsed with Et2O, and concentrated. The crude reaction was purified by column chromatography (florisil, 100-200 mesh, 2:1 Hexane: EtOAc) to achieve pure 9.

39945-51-2, The synthetic route of 39945-51-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Aquila, Brian M.; Bannister, Thomas D.; Cuny, Gregory C.; Hauske, James R.; Heffernan, Michele L.R.; Hoemann, Michael Z.; Kessler, Donald W.; Shao, Liming; Wu, Xinhe; Xie, Roger L.; US2002/177721; (2002); A1;,
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1032903-63-1, tert-Butyl 4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 6 (1.0 equiv.) was added to a solution of trisubstituted aniline 49 (5.0 g) in 100 mL CH3CN at room temperature. The resulting reaction mixture was heated to 80C and stirred for 8 h. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The mixture was stirred at 0C for 2 h and filtered. The crude product 7 was used in the next step without further purification. A small sample of 7 was recrystallised to give a brown solid, m.p. 220-221C (CH3CN/MTBE); 1H NMR delta 11.3 (s, 1H), 9.21 (s, 1H), 8.01 (m, 3H), 7.87 (m, 1H), 7.65 (m, 1H), 7.45 (m,1H), 6.73 (s, 1H), 4,59 (m, 1H), 4.28 (m, 2H), 3.27 (m, 1H), 2,79 (m,3H), 2.07 (s, 1H), 1.93 (m, 2H). 1.41-1.75 (m, 25H); 13C NMR delta 154.9,136.5, 134.2, 131.4, 125.8, 79.6, 71.7, 55.0, 38.4, 32.5, 28.5, 22.2, 18.8,15.4; HRMS (m/z) [M+Na]+ calcd for C33H44N6O7SNa 691.2890, found 691.2885., 1032903-63-1

1032903-63-1 tert-Butyl 4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate 59764580, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Haidong; Li, Yuan; Wang, Dongdong; Qin, Yu; Ji, Min; Journal of Chemical Research; vol. 39; 8; (2015); p. 475 – 477;,
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58333-75-8, 4-(2-Methoxyphenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

58333-75-8, 4-(2-Methoxyphenyl)piperidine (200 mg, 1 mmol), the product from Example 1A (228 mg, 1 mmol) and N,N-diisopropylethylamine (0.185 mL, 1.1 mmol) in toluene (8 mL) were stirred at 60 C. for 18 hours. The reaction mixture was poured into water (30 mL) and extracted with ethyl acetate (30 mL). The organic layer was washed with brine (230 mL), dried over MgSO4, filtered and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (elution with dichloromethane:methanol, 9.5:0.5) to provide the title compound 177 mg (52.3%). 1H NMR (300 MHz, DMSO-d6) ? 1.71 (m, 4H), 2.28 (m, 5H), 2.89 (m, 1H), 2.96 (m, 2H), 3.13 (s, 2H), 3.78 (s, 3H), 6.91 (m, 3H), 7.20 (m, 3H), 7.45 (m, 2H), 8.69 (s, 1H); MS (DCI/NH3) m/e 339 (M+H)+. Anal. calcd for C21H26N2O2: C, 74.52; H, 7.74; N, 8.28. Found: C, 74.23, H, 7.71, N, 8.26.

The synthetic route of 58333-75-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Stewart, Andrew O.; Kolasa, Teodozyj; US2003/232836; (2003); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-53-3,1-N-Boc-3-Cyanopiperidine,as a common compound, the synthetic route is as follows.

91419-53-3, Step 4. Piperidine-3-carbonitrile hydrochloride; A 250-mL 3-necked round-bottomed flask was charged with tert-butyl 3-cyanopiperidine-1-carboxylate (5.8 g, 27.07 mmol, 1.00 equiv, 98%) in 1,4-dioxane (60 mL). The mixture was cooled down to at 0 C. and treated with HCl (g). The mixture was stirred for 2 hours at 0 C. resulting in a precipitate that was collected by filtration to afford piperidine-3-carbonitrile hydrochloride as white solid (1.9 g, 48%).

91419-53-3 1-N-Boc-3-Cyanopiperidine 2756785, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Kalypsys, Inc; US8080566; (2011); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98977-34-5,1-tert-Butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

98977-34-5, To a stirred solution of 4-oxo-piperidine-1 ,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (14 g) in MeOH (300 mL) was added NaBhU (12 g) in 12 lots over 1 h period. After completion of addition, the reaction mixture was stirred for 30 min. Removed solvent under reduced pressure, to the residue was added saturated NH4CI solution (300 mL) and was extracted with EtOAc (300 mL). The organic layer was dried, filtered and concentrated under reduced pressure. The residue was purified by flash silica gel column chromatography by eluting with ethyl acetate to give 4-hydroxy-3-hydroxymethyl- piperidine-1-carboxylic acid tert-butyl ester (10.1 g, cis/trans mixture).

As the paragraph descriping shows that 98977-34-5 is playing an increasingly important role.

Reference£º
Patent; TRANSTECH PHARMA, INC.; GOHIMUKKULA, Devi, Reddy; JONES, David; QABAJA, Ghassan; ZHU, Jeff, Jiqun; COOPER, Jeremy, T.; BANNER, William, Kenneth; SUNDERMANN, Kurt; BONDLELA, Muralidhar; RAO, Mohan; WANG, Pingzhen; GOWDA, Raju, Bore; ANDREWS, Robert, C.; GUPTA, Suparna; HARI, Anitha; WO2011/103091; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5382-17-2,Piperidin-4-ol hydrochloride,as a common compound, the synthetic route is as follows.

a 4-Benzyl-5-bromo-2-(4-hydroxypiperidino)pyridine A mixture of 550 mg of 4-benzyl-5-bromo-2-pyridyl trifluoromethanesulfonate (Production Example 1), 600 mg of 4-hydroxypiperidine hydrochloride, 1 ml of triethylamine and 2 ml of N,N-dimethylformamide was heated under stirring for 3 hours in an oil bath kept at 100 C. in a nitrogen atmosphere. After cooling as it was, the reaction mixture was extracted with ethyl acetate/water. The organic phase was washed with water and brine, dried over anhydrous magnesium sulfate and evaporated. The residue was subjected to silica gel column chromatography and eluted with 50% ethyl acetate/hexane, to give 270 mg of the target compound. 1H-NMR (CDCl3) delta=1.44-1.60 (2H, m), 1.88-1.97 (2H, m), 3.03-3.12 (2H, m), 3.75-3.96 (3H, m), 3.99 (2H, s), 6.41 (1H, s), 7.19 (2H, d, J=7 Hz), 7.25 (1H, t, J=7 Hz), 7.32 (2H, t, J=7 Hz), 8.20 (1H, s)., 5382-17-2

The synthetic route of 5382-17-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eisai Co., Ltd.; US6599917; (2003); B1;,
Piperidine – Wikipedia
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106-52-5, 1-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Methyl-4-piperidyl para-toluenesulphonate may be obtained in the following manner: para-toluenesulphonyl chloride (19.60 g) is added in the course of approximately 1 hour 30 minutes to a solution, cooled to 0 C., of 4-hydroxy-1-methylpiperidine (11.50 g) in pyridine (50 cc), and the mixture is stirred for 4 hours at 0 C. and then 12 hours at a temperature in the region of 20 C. After the addition of triethylamine (14.10 g) and stirring for a further 15 minutes, distilled water (300 cc) and ethyl acetate (300 cc) are added., 106-52-5

As the paragraph descriping shows that 106-52-5 is playing an increasingly important role.

Reference£º
Patent; Rhone-Poulenc Sante; US5086051; (1992); A;,
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3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 80 mg (0.22 mmol) E-10 in 2 mL dioxane and 1 mL DMF is added 28 mg (0.24 mmol) 4-methyl-piperdin-4-ol and 45 mu. (0.26 mmol) diisopropylethylamin and the reaction mixture is stirred for 1 h at 130C in a microwave oven. The reaction mixture is purified by RP chromatography (C 18, 5-70% acetonitrile in water containing 0.1% formic acid). Yield: 45 mg (46%). HPLC-MS: M+H = 445; tR = 0,91 min., 3970-68-1

The synthetic route of 3970-68-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; VEEN, Van Der, Lars; KRAEMER, Oliver; WO2012/101186; (2012); A1;,
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106-52-5, 1-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Nitropyrazole (2 g, 17.69 mmol), triphenylphosphine (6.95 g, 26.54 mmol) and N-methyl-4-hydroxypiperidine (2.4 g, 21.23 mmol) were dissolved in anhydrous tetrahydrofuran (50 mL). The solution was cooled to 0 C. and diisopropylazodicarboxylate (5.4 g, 26.54 mmol) was slowly added dropwise. After the addition, the mixture was warmed to room temperature and stirred for 16 hours. The mixture was concentrated under reduced pressure and the residue was diluted with ethyl acetate (50 mL) and 3N aqueous hydrochloric acid solution (50 mL) was added. The aqueous phase was adjusted to pH=9 with saturated potassium carbonate solution and then extracted with ethyl acetate (50 mL*2). The combined organic phase was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure to give 25-c as a yellow oil (2.1 g, yield: 57%).

106-52-5, As the paragraph descriping shows that 106-52-5 is playing an increasingly important role.

Reference£º
Patent; GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.; XU, Zusheng; ZHANG, Nong; WANG, Tinghan; SUN, Qingrui; WANG, Yuguang; (90 pag.)US2018/208604; (2018); A1;,
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