Heterocyclic Building Blocks-piperidine

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324769-03-1,(3S,5R)-1-Benzyl-3,5-dimethylpiperidin-4-one,as a common compound, the synthetic route is as follows.

(3R,5S)-1-Benzyl-3,5-dimethyl-piperidin-4-one (from preparation 14) was dissolved in ethanol (200 mL) and di-tert-butyl dicarbonate (5.08 g, 23 mmol) was added, followed by palladium hydroxide on carbon (20% on carbon, 200 mg) and the reaction mixture placed under 40 atmosphere pressure of hydrogen and stirred overnight at room temperature. The reaction mixture was then filtered through a pad of Celite and Arbocel and concentrated in vacuo to afford a yellow oil which crystallised on standing to afford the title compound (5.2 g, 90%) of sufficient purity to use directly in the next stage (preparation 10). 1H NMR (400 MHz, CDCl3) delta 1.03 (6H, d), 1.49 and 1.52 [9H, 2¡Ás (Rotamers)], 2.48-2.76 (4H, m), 4.24-4.53 (2H, m).

324769-03-1, The synthetic route of 324769-03-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US2005/176772; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

73874-95-0, tert-Butyl piperidin-4-ylcarbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

73874-95-0, 10 g (0.050 mol, 1 eq) of 4-boc-amino-piperidine, 6 g (0.060 mol, 1.2 eq) of tetrahydro- 4H-pyran-4-one, 16 g (0.075 mol, 1.5 eq) of sodium triacetoxyborohydride, and 3 g (0.050 mol, 1 eq) of acetic acid were combined in 600 mL of dichloroethane and stirred at ambient temperature. After two days, the reaction was washed with 2 x 200 mL saturated sodium bicarbonate. The organic layer was separated, dried with sodium sulfate, and evaporated to yield 9.2 g (65% yield) of 1 ,1-dimethylethyl [1-(tetrahydro-2H-pyran-4-yl)-4- piperidinyl]carbamate as a white solid. 1H-NMR (400 MHz, DMSO-Of6): delta 6.73 (d, J = 7.6 Hz, 1 H), 3.86 (m, 2H), 3.24 (app t, 2H), 3.16 (m, 1 H), 2.81 (m, 4H), 2.37 (m, 1 H), 2.07 (app t, 2H), 1.73-1.59 (m, 4H), 1.44-1.24 (m, 4H), 1.37 (s, 9H).

The synthetic route of 73874-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/36711; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138163-07-2,1-Benzyl 4-methyl piperidine-1,4-dicarboxylate,as a common compound, the synthetic route is as follows.

General procedure: A 0.2 M solution of the corresponding methyl ester in aq NH4OH (28-30%) was stirred at r.t. for 16 h. The solvent was evaporated to affordthe amide, which was, in some cases, purified by silica gel chromatography. The known amides 3, 33 5a,34 5b, 6c 5h,35 11a,36 11b,37 11c,3611e,38 11h,4 11i,39 11j,39 13,40 14,41 20,42 and 2343 were synthesized following the general procedure described above. Compound 5e was synthesized following the literature.44, 138163-07-2

The synthetic route of 138163-07-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Keita, Massaba; Vandamme, Mathilde; Paquin, Jean-Francois; Synthesis; vol. 47; 23; (2015); p. 3758 – 3766;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

290328-55-1, 4-(Methylsulfonyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3 Preparation of (S)-benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-((2-(4-(methylsulfonyl)piperidin-1-yl)ethyl)amino)-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)cyclohex-3-enecarboxylate To a flask containing a suspension of (S)-benzyl 4-((1R,3 aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(aziridin-1-yl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)cyclohex-3-enecarboxylate (0.044 g, 0.067 mmol) in 1,4-dioxane (2 mL) was added Hunig’s base (0.070 mL, 0.402 mmol) followed by 4-(methylsulfonyl)piperidine, HCl (0.067 g, 0.335 mmol). The flask attached to a reflux condensor and was heated to 95 C. for 15 h, then was cooled to rt. The crude mixture was adsorbed to silica gel and was purified by flash chromatography using a 10-75% ethyl acetate in hexanes gradient and a 12 g silica gel column. The fractions containing the expected product were combined and concentrated under reduced pressure to give (S)-benzyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-((2-(4-(methylsulfonyl)piperidin-1-yl)ethyl)amino)-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)cyclohex-3-enecarboxylate (0.033 g, 0.041 mmol, 60.6% yield) as a clear, colorless film. LCMS: m/e 813.8 (M+H)+, 2.17 min (method 1). 1H NMR (500 MHz, chloroform-d) delta=7.40-7.29 (m, 5H), 5.37-5.33 (m, 1H), 5.16 (dd, J=6.1, 1.7 Hz, 1H), 5.14 (s, 2H), 4.71 (d, J=1.7 Hz, 1H), 4.59 (s, 1H), 3.17-3.06 (m, 2H), 2.83 (s, 3H), 2.86-2.78 (m, 1H), 2.65-2.53 (m, 4H), 2.49-2.42 (m, 2H), 2.38-2.30 (m, 2H), 2.19-2.12 (m, 4H), 1.69 (s, 3H), 1.08 (s, 3H), 0.96 (s, 6H), 0.89 (s, 3H), 0.85 (s, 3H), 2.12-0.82 (m, 29H)., 290328-55-1

290328-55-1 4-(Methylsulfonyl)piperidine 22275038, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; Swidorski, Jacob; Meanwell, Nicholas A.; Regueiro-Ren, Alicia; Sit, Sing-Yuen; Chen, Jie; Chen, Yan; US2013/210787; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1209780-71-1, tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tert-butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate (8-1) (100 mg, 0.42 mmol) and tetrahydrofuran (5 mL) were added to a 25 mL flask, and cooled to 0 C under protection of nitrogen, sodium hydride (20 mg, 0.5 mmol) was added thereto, and the reaction was performed for 30 minutes. Iodomethane (120 mg, 0.84 mmol) was then added thereto, and the reaction was performed for 16 hours. The reaction solution was slowly poured into water, and a crude product of the title compound 100 mg was obtained after work-up, and was used directly for the next reaction without purification. ESI-MS (m/z): 252.2 [M+H]+,, 1209780-71-1

1209780-71-1 tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate 56932106, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.; SONG, Shuai; CAI, Jiaqiang; TIAN, Qiang; ZENG, Hong; SONG, Hongmei; DENG, Hanwen; TANG, Zujian; DUAN, Xiaofan; LONG, Rongrong; LIU, Yao; WANG, Lichun; WANG, Jingyi; (80 pag.)EP3508483; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79421-45-7,79421-45-7, 1-(4-Nitrophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 6 Synthesis of Compound 13 [Show Image] Compound 12 (1.50 g, 6.75 mmol) was dissolved in methanol (25 ml), 10% palladium-carbon (150 mg) was added, and the interior of the system was replaced with a hydrogen gas. After stirred at room temperature for 2 hours, the reaction solution was filtered using Celite, and washed with methanol. The filtrate, and the washing solution were combined, and the solvent was distilled off under reduced pressure to obtain Compound 13 (1.28 g, yield 99%). 1H-NMR (CDCl3 / TMS) deltappm: 1.70-1.80 (m, 2H), 2.07 (br, 2H), 2.84 (br, 2H), 3.37 (br, 3H), 3.85 (br, 1H), 6.65 (d, J = 8.4Hz, 2H), 6.91 (br, 2H).

As the paragraph descriping shows that 79421-45-7 is playing an increasingly important role.

Reference£º
Patent; SHIONOGI & CO., LTD.; EP1988077; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1155-56-2,1-Benzyl-N-phenylpiperidin-4-amine,as a common compound, the synthetic route is as follows.

Reference Example 2 N-(1-Benzyl-4-piperidinyl)-N-phenylacetamide (1-Benzyl-4-piperidinyl)-phenylamine obtained in Step1 of Reference Example 1 was heated in acetic anhydride at 70C to obtain the oily title compound.

1155-56-2, 1155-56-2 1-Benzyl-N-phenylpiperidin-4-amine 70865, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1559428; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.104-58-5,3-(Piperidin-1-yl)propan-1-ol,as a common compound, the synthetic route is as follows.

General procedure: Sodium (1.2 mmol) was added to a solution of an alcohol (1.0 mmol) in dry THF and the mixture was stirred at rt for 1 h. 4-Chloroquinazoline [22] (6, 1.0 mmol) was then added, and the resultant solution was stirred at rt for 24 h. The mixture was diluted with ethyl acetate (10 mL), washed with brine (10 mL) and dried over sodium sulfate. The products were purified by column chromatography (hexane-ethyl acetate 8:2).

104-58-5, As the paragraph descriping shows that 104-58-5 is playing an increasingly important role.

Reference£º
Article; ?pulak, Marcel; Pourova, Jana; Vopr?alova, Marie; Miku?ek, Ji?i; Kune?, Ji?i; Vacek, Jan; Ghavre, Mukund; Gathergood, Nicholas; Pour, Milan; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 65 – 72;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

324769-06-4, 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Stage (ii): tert-Butyl 4-(4-methoxybenzylamino)-3,3-dimethylpiperidine-1-carboxylate tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (3.3 g, 14.53 mmol, 1 eq) and 4-methoxybenzylamine (3.98 g, 29.07 mmol, 2 eq) were dissolved in dichloromethane (40 ml), and stirring was carried out for 2 h at RT. The reaction mixture was cooled to 0 C., and Na(OAc)3BH (9.24 g, 43.61 mmol, 3 eq) was added in portions. Then stirring was carried out for 16 h at RT. The reaction mixture was diluted with dichloromethane (150 ml), washed with water and sat. NaCl solution (in each case 100 ml), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (Alox neutral, 10% ethyl acetate in hexane) (colourless oil). Yield: 38% (1.948 g, 5.59 mmol).

324769-06-4, 324769-06-4 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine 22278899, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; GRUENENTHAL GmbH; US2012/71461; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

84964-24-9, 1-(3-Bromophenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84964-24-9, In the reaction tube by sequentially adding a 1 e (0.5 mmol, 120 mg), 2 a (0.5 mmol, 75 mg), acetonitrile (3 ml), ferric chloride (0.05 mmol, 8.1 mg), di-tert-butyl peroxide (0.5 mmol, 92 mul) and 4 – dimethylamino pyridine (0.05 mmol, 6.1 mg), in oxygen (1 atm) atmosphere at 60 C stirring reaction 24 h. Then, by adding 10 ml saturated salt water quenching reaction, extracted with ethyl acetate (10 ml ¡Á 3), combined with the organic phase, dried with anhydrous sodium sulfate. Filtering, turns on lathe does, too separating by silica gel column (petroleum ether/ethyl acetate=10/1) to obtain white solid product 3 e (101 mg, 55%). The compound of the characterization data are as follows:

As the paragraph descriping shows that 84964-24-9 is playing an increasingly important role.

Reference£º
Patent; Henan Normal University; Fan Xuesen; Shi Xiaonan; Zhang Xinying; He Yan; (18 pag.)CN107501278; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem