Heterocyclic Building Blocks-piperidine

154775-43-6, 3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,154775-43-6

Step A Iodomethane (556 muL, 8.93 mmol) was added dropwise to a cooled (0 C.) mixture of commercially available 3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propanoic acid (2.09 g, 8.12 mmol) and K2CO3 (2.81 g, 20.3 mmol) in 20 mL of DMF. The reaction mixture was permitted to warm to rt and stir overnight. The reaction mixture was diluted with ether and washed four times with water, then once with brine. The ethereal layer was dried over anhydrous MgSO4, filtered, and concentrated. Purification by MPLC (silica, 40% ethyl acetate/hexanes) provided tert-butyl 4-(3-methoxy-3-oxopropyl)piperidine-1-carboxylate:

The synthetic route of 154775-43-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Goble, Stephen D.; Mills, Sander G.; Yang, Lihu; Pasternak, Alexander; US2007/238723; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71233-25-5,1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate,as a common compound, the synthetic route is as follows.,71233-25-5

G. 5-Amino-3,6-dihydro-2H-pyridine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (35a2) To a solution of 34a2 (24 g, 88.5 mmol) was added ammonium in EtOH (88 mL, 180 mmol, 2M). The reaction mixture was heated to 60 C for 3 h. The solvent was evaporated under reduced pressure to afford a yellow solid (23 g, 91.5percent). MS (ES+): m/z=271 (M+1)

The synthetic route of 71233-25-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hurley, Timothy Brian; Lee, Kwangho; Peukert, Stefan; Wattanasin, Sompong; US2009/325948; (2009); A1;,
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Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24211-55-0,(S)-Piperidin-3-ol,as a common compound, the synthetic route is as follows.

2,3′-difluoro-4′-((1-(2-fluoro-2-methylpropyl)piperidin-4-yl)methoxy)biphenyl-4-carboxylic acid (0.04 g, 0.10 mmol) and (S)-piperidin-3-ol (0.02 g, 0.19 mmol) were dissolved in DMF 2 mL. DIPEA (0.08 mL, 0.48 mmol), EDCI (0.04 g, 0.19 mmol) and HOBt (0.03 g, 0.19 mmol) were added thereto slowly, following with stirring at 60 C. for 3 hours. After the completion of the reaction, excess amount of water was added to the reaction mixture. The resulting precipitate was filtered, and dissolved in CH2Cl2. The solution was concentrated under reduced pressure. The obtained concentrate was purified by column chromatography (40 g ISCO silica gel cartridge, 0-20% MeOHCH2Cl2) to yield the title compound as light-yellow solid (0.02 g, 42%). 1H NMR (400 MHz, CDCl3) delta 7.40 (t, 1H, J=5.8 Hz), 7.29-7.21 (m, 4H), 6.99 (t, 1H, J=6.4 Hz), 3.88 (d, 2H, J=4.6 Hz), 3.78-3.27 (m, 4H), 2.97 (d, 2H, J=8.2 Hz), 2.45 (s, 1H), 2.40 (s, 1H), 2.16 (t, 2H, J=8.5 Hz), 1.91-1.65 (m, 7H), 1.45-1.23 (m, 8H); MS (ESI) mz 505 (M++H)

24211-55-0, The synthetic route of 24211-55-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, ChangSik; Jang, TaegSu; Choi, DaeKyu; Ko, MooSung; Kim, DoHoon; Kim, SoYoung; Min, JaeKi; Kim, WooSik; Lim, YoungTae; US2015/166480; (2015); A1;,
Piperidine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-48-6,tert-Butyl 4-carbamoylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

91419-48-6, 2) Second Step: Synthesis of the t-butyl ester of 4-cyanopiperidine-1-carboxylic acid 2.05 g (9 mmol) of the t-butyl ester of 4-carbamoylpiperidine-1-carboxylic acid as obtained in the first step above were introduced into a Schlenck tube in the presence of 1.7 ml of DIEA (1-1 eq.). The medium was flushed under argon, and 18 ml of anhydrous THF were then added. The reaction medium was then cooled to a temperature of 0 C. and 1.38 ml of trifluoroacetic anhydride (1.1 eq.) were added dropwise. The medium then became totally clear. If the reaction is not complete after 1 hour, a further 0.5 equivalent of DIEA and then of trifluoroacetic anhydride are added. The reaction was monitored by TLC, staining with ninhydrin. At the end of the reaction, the organic phase was washed successively with aqueous solutions of 5% NaHCO3, 0.1N KHSO4 and saturated NaCl solution. The expected product was not visible under UV light. In the event of appearance of a UV-visible compound, a purification by flash chromatography in a gradient of eluent ranging from cyclohexane up to a 9/1 cyclohexane/ethyl acetate mixture may be performed. 1.1 g of a very pale yellow liquid that solidified after a few hours were obtained.1H NMR: (CDCl3): 3.63 (m, 2H), 3.36 (m, 2H), 2.8 (m, 1H), 1.84 (m, 4H), 1.45 (s, 9H).MS m/z: 211 (M++1)

91419-48-6 tert-Butyl 4-carbamoylpiperidine-1-carboxylate 2735646, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Institut Pasteur De Lille; Centre National De La Recherche Scientifique; Universite De Lille 2, Universite Du Droit Et De La Sante; Institut National De La Sante Et De La Recherche Medicale (Inserm); US2011/136823; (2011); A1;,
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50585-89-2, Methyl piperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50585-89-2, Potassium 3-methoxycarbonyl-piperidine-1-carbodithioate (13 Kmpc) was prepared by the dropwise addition of 14 CS2 (1.2mL, 20mmol) into a solution of methyl nipecotate (2.8mL, 20mmol) in 15 methanol (30mL) in the presence of 16 KOH (1.2g, 20mmol), stirring the reaction mixture for 1h. The yellow solid which separated was filtered off, washed with ethanol and thereafter with ether and dried (Scheme 2 ). Yield: 80%; m.p. 202C. Anal. Found: C, 37.15; H, 4.88; N, 5.70; S, 24.58%. Calc. for C8H12NO2S2K (257.40): C, 37.32; H, 4.70; N, 5.44; S, 24.91%. IR (KBr, cm-1): nu(C-H) 2944, 2857; nu(C=O) 1658; nu(CN) 1565; nu(C=S) 1012. 1H NMR (CDCl3: delta, ppm): 1.68-2.43 (m, H-3, H-4, H-5), 2.64 (t, 2H, H-6axial), 2.91 (d, 2H, H6-equatorial), 2.82 (t, 2H, H-2axial), 3.13 (d, 2H, H-2equatorial), 4.09 (s, 3H, -OCH3). 13C NMR (CDCl3: delta, ppm): 23.88-49.99 (piperidine ring), 51.01 (-OCH3), 173.50 (C=O), 212.46 (C=S).

The synthetic route of 50585-89-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nath, Paras; Bharty; Kushawaha; Maiti; Polyhedron; vol. 151; (2018); p. 503 – 509;,
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1022150-11-3, (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 2.5g (5.1mmol) of formula 10 was added to the methanol solution in 25ml of hydrochloric acid, stirred at room temperature 2hour. Concentrated under reduced pressure, the residue was added 30ml of water, extracted with ethyl acetate, the organic phase was washed with 5% aqueousSodium hydroxide solution was washed until neutral. The organic phase was concentrated under reduced pressure to give a pale yellow oil 1.82g, yield 92%

1022150-11-3, The synthetic route of 1022150-11-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Okuura Dayton (Shanghai) Pharmaceutical Co., Ltd.; Yu, Libing; Guo, Maojun; Yang, Qingang; Ren, Huasen; (19 pag.)CN105622613; (2016); A;,
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37675-18-6, (S)-Ethyl piperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 5 To a mixture of (S)-ethyl nipecotate (1.15 g) and tetrahydrofuran (16 ml) was added lithium aluminum hydride (278 mg) at 0C. The mixture was stirred for 3 hours with elevating the temperature to room temperature. Water (0.28 ml), 25% potassium hydroxide solution (0.28 ml) and water (0.84 ml) were added thereto in this order, and the mixture was stirred for 15 hours. The insolubles were filtered off using celite and the mother liquor was concentrated, to give (S)-3-(hydroxymethyl)piperidine (797 mg). [alpha]D = -11.3 (c = 0.730, MeOH). 1H-NMR (300 Hz, CDCl3) delta: 1.07-1.20 (1H, m), 1.40-1.54 (1H, m), 1.61-1.82 (3H, m), 2.39 (1H, dd, J=12.0 and 9.9 Hz), 2.54-2.62 (3H, m), 2.95-3.01 (1H, m), 3.13-3.18 (1H, m), 3.40-3.54 (2H, m).

37675-18-6, The synthetic route of 37675-18-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1553074; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.268550-48-7,tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate,as a common compound, the synthetic route is as follows.

5-Bromo-3,4-dichloro-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine (225 mg, 0.70 mmol) and 8- boc-2,8-diaza-spiro-[4.5]decan-1-one (197 mg, 0.77 mmol) were loaded in a microwave vial. The capped vial was evacuated using high vacuum and purged with nitrogen (each three times). Triethylamine (0.27 mL, 2.11 mmol) and NMP (2.3 mL) were added and the mixture was degassed by using the high vacuum and purged with nitrogen three times. The reaction mixture was heated in the microwave at 220 C for 1 h before it was cooled and dropped in vigorously stirred water (8 mL). The resulting precipitate was filtered off and the residue was purified by chromatography on silica gel (dichloromethane/ethanol) to give the title compound as a light brown solid (153 mg, 50%). 1H-NMR (500 MHz, CDCl3) ppm = 8.47 (s, 1H), 6.53 (bs, 1 H), 5.90 (s, 2H), 3.52 – 3.32 (m, 6H), 2.25 – 2.10 (m, 4H), 2.01 (s, 6H), 1.58 (d, J=13.0, 2H). HRMS m/z (ESI+) [M+H]+ C19H22BrClN4O, calc 437.0738, found 437.0733, Rt = 3.05 min (HPLC method B).

268550-48-7, The synthetic route of 268550-48-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, kai; STIEBER, Frank; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; WO2014/63778; (2014); A1;,
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160296-40-2, tert-Butyl 4-(4-fluorobenzoyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

60% Sodium hydride (717mg, [18MMOL)] was suspended in anhydrous dimethylformamide [(50ML)] under nitrogen at [5C.] To this was added portion-wise 6-bromo naphthalene-2-thiol (3.89g, 16mmol). The mixture was stirred at [5C] for 30 minutes. 1- (t- [BUTOXYCARBONYL)-4- (4-FLUOROBENZOYL) PIPERIDINE] (Reference Example 12; [5.] 00g 16mmol) was then added to the solution and the reaction heated at [60C] for 16 hours. The solution was poured into water [(75ML)] and washed with EtOAc [(2X75ML).] The organic phases were combined then washed with water then brine. The solution was dried over MgS04, after filtration and evaporation a solid was isolated. This was recrystallised from EtOAc/isohexane resulting in a cream solid (2.96g, 35%). NMR (DMSO-d6) 1.37 (s, [11H),] 1.72 (m, 2H), 2.86 (m, 2H), 3.52 (m, 1H), 3.92 (m, 2H), 7.31 (d, 2H), 7.55 (d, 1H), 7.69 (d, 1H), 7.93 (m, 4H), 8.17 (s, 1H), 8.26 (s, 1H) ; m/z 470., 160296-40-2

The synthetic route of 160296-40-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/33427; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

91419-52-2, 1-Boc-4-Cyanopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91419-52-2, 4-Cyanopiperidine-1-formic acid tert-butyl ester (3.00 g, 14.27 mmol) was dissolved in tetrahydrofuran (30.00 mL), slowly added dropwise with lithium hexamethyldisilazide (1M, 28.54 mL) at -78 C and under nitrogen protection, stirred for 1 hour, slowly added dropwise with ethyl chloroformate (3.10 g, 28.54 mmol), and then stirred under nitrogen protection at -78 C for 1 hour. TLC showed that the reaction was complete. The reaction solution was quenched with a saturated solution of sodium bicarbonate (15 mL), and extracted with ethyl acetate (20 mL x 2), and the combined organic phases were washed with a saturated solution of ammonium chloride (50 mL), dried over anhydrous sodium sulfate (10 g), filtered and concentrated to give 1E. 1H NMR (400MHz, DMSO-d6) delta= 4.23 (q, J = 7.1 Hz, 2H), 4.00 – 3.92 (m, 2H), 2.95 (br, 2H), 2.07 (br d, J = 13.3 Hz, 2H), 1.89 – 1.76 (m, 2H), 1.40 (s, 9H), 1.24 (t, J = 7.1 Hz, 3H).

91419-52-2 1-Boc-4-Cyanopiperidine 1514443, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Medshine Discovery Inc.; LIU, Xile; DING, Charles Z.; CHEN, Shuhui; WU, Lingyun; HU, Lihong; WAN, Haiwen; (118 pag.)EP3567030; (2019); A1;,
Piperidine – Wikipedia
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