Heterocyclic Building Blocks-piperidine

138022-02-3, tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-{[(4-Cyano-benzoyl)-methyl-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester To a stirred solution of 4-cyanobenzoic acid (322 mg, 2.19 mmol) in CH2Cl2 (10 mL) was added TBTU (702 mg, 2.19 mmol) and N,N-diisopropylethylamine (1.14 mL, 6.54 mmol) and the reaction mixture stirred at RT for 10 min. 4-Methylaminomethyl-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 2.19 mmol) in DMF (4 mL) was added and the reaction mixture was stirred at RT for 2 h. The crude material was concentrated in vacuo and purified by silica gel column chromatography, eluting with isohexane and increasing the polarity to 100percent EtOAc to afford 4-{[(4-cyano-benzoyl)-methyl-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester as a orange solid (700 mg, 89percent). AnalpH2_MeOH-4 min(1): Rt 2.73 min; m/z 358 [M+1]+.

138022-02-3, The synthetic route of 138022-02-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ashworth, Alan; Lord, Christopher James; Elliot, Richard James Rowland; Niculescu-Duvaz, Dan; Porter, Roderick; Boffey, Raymond John; Bayford, Melanie Jayne; Firth-Clark, Stuart; Jarvis, Ashley Nicholas; Perrior, Trevor Robert; Key, Rebekah Elisabeth; US2015/99732; (2015); A1;,
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Piperidine | C5H11N – PubChem

140645-23-4, (R)-1-Boc-3-(Aminomethyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(R)-tert-butyl 3-(((3-amino-6-bromopyrazine-2-yl)amino)methyl)piperidine- 1 -carboxylate._10239] (R)-tert-butyl 3-(aminomethyl)piperidine-1 -carboxylate (4.97 g, 22.40 mmol) was dissolved in DMSO (80 ml), and then 3,5-dibromopyrazine-2-amine (8.5 g, 33.60 mmol) and Et3N (6.3 ml) were added, followed by stirring at 130 C. overnight. Afier the completion of the reaction, the reaction mixture was extracted with H20, EA, and brine, followed by drying (Na2SO4), filtration, and concentration under reduced pressure, and the residue was purified by column chromatography (EA:Hex=1:1), to give (R)-tert-butyl 3-(((3-amino-6-bromopyrazine-2-yl)amino)methyl)piperi- dine-i-carboxylate (2.19 g, two steps: 26%).10240] ?H-NMR (300 MHz, CDC13) oe 7.39 (s, 1H), 4.64-4.23 (m, 2H), 3.79-2.92 (m, 5H), 2.25-1.19 (m, 4H), 1.46 (s, 9H)

140645-23-4, 140645-23-4 (R)-1-Boc-3-(Aminomethyl)piperidine 1502023, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.; Jung, Hee Jung; Ha, Jae Du; Cho, Sung Yun; Kim, Hyoung Rae; Lee, Kwang Ho; Lee, Chong Ock; Choi, Sang Un; Park, Chi Hoon; US2015/259350; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1465-76-5, 1-(tert-Butyl)piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1465-76-5, Step A: 1-tert-Butylpiperidin-4-ol To a 0 C. solution of 1.0 g of 1-tert-butylpiperidin-4-one (COMPOUND PPA-1) in 2 mL of TBF was added 6.4 mL of a 1M solution of lithium aluminum hydride in THF dropwise. The mixture was stirred 10 min at rt, then quenched by careful addition of 0.2 mL of water, 0.2 mL of 15% aqueous NaOH, and 0.6 mL of water. The mixture was stirred vigorously for 30 min, then filtered and concentrated to yield the title compound.

As the paragraph descriping shows that 1465-76-5 is playing an increasingly important role.

Reference£º
Patent; Doherty, James B.; Stelmach, John E.; Chen, Meng-Hsin; Liu, Luping; Hunt, Julianne A.; Ruzck, Rowena D.; Goulet, Joung L.; Wisnoski, David D.; Natarajan, Swaminathan Ravi; Rupprecht, Kathleen M.; Bao, Jianming; Miao, Shouwu; Hong, Xingfang; Sinclair, Peter J.; Kallashi, Florida; US2003/92712; (2003); A1;,
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479630-08-5, 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 47A Tert-butyl 4-[10-nitro-2-oxo-8-(trifluoromethyl)-1,2-dihydropyrimido[1,2-b]indazol-4-yl]piperidine-1-carboxylate Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate (1.00 g, 3.34 mmol, 1.5 eq), 4-nitro-6-(trifluoromethyl)-1H-indazol-3-amine (548 mg, 2.23 mmol, 1 eq) and potassium phosphate (945 mg, 4.45 mmol, 2 eq) were suspended in 1-methoxy-2-propanol (10 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180 C. for 15 min After cooling to RT, the suspension was diluted with 20 mL dichloromethane/methanol (4:1), filtered through a short pad of silica gel with 100 mL dichloromethane/methanol (4:1) and evaporated in vacuo. The residue was purified by preparative HPLC (Method 1A). The combined product fractions were concentrated in vacuo to remove acetonitrile. The resulting suspension was filtered, the residue was washed with water (2 ml) and dried for 16 h at 50 C. in vacuo to give the title compound (90.8 mg, 8% of theory). LC-MS (Method 1B): Rt=1.16 min, MS (ESIPos): m/z=482 [M+H]+

479630-08-5, As the paragraph descriping shows that 479630-08-5 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; Hassfeld, Jorma; KINZEL, Tom; Koebberling, Johannes; CANCHO GRANDE, Yolanda; BEYER, Kristin; Roehrig, Susanne; Koellnberger, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; US2015/126449; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373603-88-4,3,3-Dimethylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

General procedure: In an oven-dried RB flask, compound 6c (250mg, 1.01mmol) and formaldehyde solution, 37-41wt.% in water (0.15mL, 2.02mmol) were mixed in glacial acetic acid (5mL). Morpholine (220.4mg, 2.53mmol) was added drop wise at 0C. The resulting mixture was stirred at room temperature for 12h. After completion of the reaction, the excess solvent was evaporated to dryness under reduced pressure. The residue was neutralized with 10% NaHCO3 solution, the solid formed was collected by filtration, washed with water and dried. The crude product was purified by silica gel column chromatography to provide title compound.

373603-88-4, The synthetic route of 373603-88-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jose, Gilish; Kumara, T. H. Suresha; Nagendrappa, Gopalpur; Sowmya; Jasinski, Jerry P.; Millikan, Sean P.; More, Sunil S.; Janardhan, Bhavya; Harish; Chandrika; Journal of Molecular Structure; vol. 1081; (2015); p. 85 – 95;,
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336191-17-4, tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

336191-17-4, EXAMPLE 16; 8-(5-{[(4-Aminobiphenyl-3-yl)amino]carbonyl}pyridin-2-yl)-N-(2-phenylethyl)-2,8-diazaspiro[4.5]decane-2-carboxamide; To a solution of methyl 6-chloronicontinate (200 mg, 1.16 mmol) in DMSO/PhMe (2 mL of a 1:1 solution) was added t-butyl-2,8-diazaspiro[4.5]decane-2-carboxylate (700 mg, 2.91 mmol). The reaction mixture was heated at 85 C. for 6 hours and then diluted with EtOAc (10 mL). The organic layer was washed with NaHCO3 (1¡Á5 mL) and brine (1¡Á5 mL), dried over Na2SO4, and then concentrated. The crude residue was purified by reverse-phase flash chromatography (10-100% MeCN/H2O with 0.05% TFA) to give t-butyl 8-[5-(methoxycarbonyl)pyridin-2-yl]-2,8-diazaspiro[4.5]decane-2-carboxylate: MS (ESI+): cal’d [M+H]+ 376.2, obs’d 376.2.

336191-17-4 tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate 34178604, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Berk, Scott C.; Close, Joshua; Hamblett, Christopher; Heidebrecht, Richard W.; Kattar, Solomon D.; Kliman, Laura T.; Mampreian, Dawn M.; Methot, Joey L.; Miller, Thomas; Sloman, David L.; Stanton, Matthew G.; Tempest, Paul; Zabierek, Anna A.; US2007/117824; (2007); A1;,
Piperidine – Wikipedia
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385425-15-0, 1-(4-Iodophenyl)piperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under room temperature, will be sequentially 1 – (piperidin-2-oxo-1-yl) – 4-iodophenylamino (2.5 g, 8.3 mmol), 1 – (3-fluoro-4-ethoxy phenyl) – 7-oxo -4, 5, 6, 7-tetrahydro -1H-pyrazolo [3,4-c] pyridine-3-carboxylic acid ethyl ester (2.4 g, 6.9 mmol) and potassium carbonate (2.1 g, 15.1 mmol) by adding DMSO in (35 ml). Under the protection of nitrogen is added in the mixture of the obtained CuI (650 mg, 3.4 mmol) and 1,10-phenanthrene (613 mg, 3.4 mmol). The obtained mixture is heated to 120 C, reaction 12 hours. After the completion of the reaction, the obtained cooling to room temperature the mixture, adding water. The resulting mixture is extracted with ethyl acetate. The resulting organic phase is concentrated under reduced pressure to obtain crude products. Crude product is purified by silica gel column chromatography (PE:EA=1:1) to obtain 1.0 g (yield: 26.7%) of the product., 385425-15-0

The synthetic route of 385425-15-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CSPC Weisheng Pharmaceutical Technology (Shijiahuang) Co., Ltd.; Shi, Ying; Gao, Qingzhi; Mi, Yi; Wang, Xuliang; (129 pag.)CN105384739; (2016); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138227-63-1,tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Reference Example 6 N-[4-(1-t-Butoxycarbonylpiperidin-4-yloxy)phenyl]ethanesulfonamide To a solution of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)aniline (10.6 g) and pyridine (8 ml) in dichloromethane (75 ml) was added dropwise ethanesulfonyl chloride (4.1 ml) in an ice bath and the mixture was stirred at room temperature for 5 hours. After addition of methanol (1 ml), the reaction mixture was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=3/2 as an eluant to give the desired compound (11.7 g, yield 84%) as a pale pink solid. 1H NMR (400 MHz, CDCl3) delta ppm: 1.38 (3H, t, J=8.0), 1.47 (9H, s), 1.74 (2H, m), 1.90 (2H, m), 3.07 (2H, q, J=8.0), 3.34 (2H, m), 3.69 (2H, m), 4.42 (1H, m), 6.88 (2H, d, J=9.0), 7.17 (2H, d, J=9.0)., 138227-63-1

138227-63-1 tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate 22181157, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Sankyo Company, Limited; US6555556; (2003); B1;,
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Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71486-53-8,Methyl 4-oxopiperidine-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

71486-53-8, Referential Example 8 1.94 g of methyl 4-oxo-3-piperidinecarboxylate hydrochloride, 1.68 g of sodium hydrogencarbonate and 1.67 g of ethyl bromoacetate were dissolved in a mixed solvent comprising 32 ml of water and 8 ml of diethyl ether and stirred at room temperature overnight. 50 ml of ethyl acetate was added to the reaction liquid, and the organic layer was separated by liquid-liquid separation. This was dried with sodium sulfate and concentrated. The resulting residue was purified by silica gel column chromatography (using a gradient eluent of chloroform to chloroform/methanol=100/1) to obtain 1.5 g of ethyl 3-methoxycarbonyl-4-oxo-1-piperidineacetate as an oily substance. Mass spectrum (m/z): FAB (Pos) 244(M+ +1) NMR spectrum (CDCl3, TMS internal standard):

The synthetic route of 71486-53-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US5773442; (1998); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.385425-15-0,1-(4-Iodophenyl)piperidin-2-one,as a common compound, the synthetic route is as follows.

Example 52 1-(4-Methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid (61). A solution of 1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester (50, 2.0 g, 6.4 mmol), 1-(4-iodo-phenyl)-piperidin-2-one (60, 2.5 g, 8.3 mmol, 1.3 equiv), and K2CO3 (325 mesh powder, 1.80 g, 12.8 mmol, 2.0 equiv) in DMSO (35 mL) was degassed three times under a steady nitrogen stream before being treated with CuI (244 mg, 1.3 mmol, 20% equiv) and 8-hydroxyquinoline (189 mg, 1.3 mmol, 20% equiv) under N2. The resulting reaction mixture was subsequently degassed three times again before being warmed up to 125 C. for 10 h. When HPLC showed the coupling reaction was complete, the reaction mixture was cooled down to 5-10 C. before being treated with 14% NH4OH aqueous solution (30 mL) and ethyl acetate (30 mL) at 5-10 C. with good stirring. The mixture was stirred for an additional 1 h at 5-10 C. The mixture was filtered through a Celite bed and the Celite bed was washed with water (2*10 mL). The two layers of the filtrates were separated, and the aqueous layer was acidified by 1 N aqueous HCl solution to pH=4. The mixture was subsequently stirred at 5-10 C. for an additional 1 h. The solids were collected by filtration, washed with water (2*5 mL), and dried in vacuo at 40-45 C. for 12 h to afford the crude desired 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid (61, 2.0 g, 2.95 g theoretical, 68%), which was found to be pure enough to do the following reaction without further purification. For 61, CIMS m/z 461 (M++H, C25H24N4O5)., 385425-15-0

As the paragraph descriping shows that 385425-15-0 is playing an increasingly important role.

Reference£º
Patent; Zhou, Jiacheng; Oh, Lynette M.; Ma, Philip; Li, Hui-Yin; Confalone, Pasquale; US2003/181466; (2003); A1;,
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