So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Qiao, Jennifer X.; Chang, Chong-Hwan; Cheney, Daniel L.; Morin, Paul E.; Wang, Gren Z.; King, Sarah R.; Wang, Tammy C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; Wexler, Ruth R.; Lam, Patrick Y. S. researched the compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate( cas:145166-06-9 ).SDS of cas: 145166-06-9.They published the article 《SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa》 about this compound( cas:145166-06-9 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: Factor Xa selective inhibitor SAR bisacylaminocycloalkane preparation anticoagulant; crystal structure bisacylaminoethane bisacylaminocycloalkane Factor Xa complex; mol structure bisacylaminoethane bisacylaminocycloalkane Factor Xa complex; acylaminocyclopentane Factor Xa selective inhibitor SAR preparation anticoagulant; acylaminocyclohexane Factor Xa selective inhibitor SAR preparation anticoagulant. We’ll tell you more about this compound (cas:145166-06-9).
In the search of Factor Xa (FXa) inhibitors structurally different from the pyrazole-based series, the authors identified a viable series of enantiopure cis-(1R,2S)-bis(acylamino)cycloalkanes as potent and selective inhibitors of FXa. Among them, I and II were the most potent neutral compounds, and had good anticoagulant activity comparable to the pyrazole-based analogs. Crystal structures of I-FXa and II-FXa illustrate binding similarities and differences between the five- and the six-membered core systems, and provide rationales for the observed SAR of P1 and linker moieties G and Z in III (n = 1, 2).
The article 《SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa》 also mentions many details about this compound(145166-06-9)SDS of cas: 145166-06-9, you can pay attention to it or contacet with the author([email protected]) to get more information.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem