Rapid Synthesis of Polycyclic Aromatic Compounds by Iodocyclization of Ynamides was written by Okitsu, Takashi;Itoh, Maho;Inui, Ayaka;Muta, Emiko;Nakamoto, Ryota;Adachi, Yuta;Wada, Akimori;Hatano, Manabu. And the article was included in Asian Journal of Organic Chemistry in 2022.Application In Synthesis of 1-Tosylpiperidin-4-one This article mentions the following:
The iodocyclization of ene-ynamides, e.g., N-((2-(Cyclohept-1-en-1-yl)phenyl)ethynyl)-N,4-dimethylbenzenesulfonamide leading to naphthalenes, e.g., I and phenanthrenes, e.g., II has been described. These reactions were completed within 3 s by using I(coll)2PF6 as an iodonium reagent, and cyclized products were obtained in good to high yields. This method is the most rapid synthesis known to date of polycyclic aromatic compounds In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Application In Synthesis of 1-Tosylpiperidin-4-one).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Application In Synthesis of 1-Tosylpiperidin-4-one
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem