Ohrui, Sayaka published the artcileDesign and synthesis of novel orexin antagonists via structural simplification of the morphinan skeleton, Product Details of C18H23NO2, the main research area is orexin ligand spiro piperidine antagonist preparation.
Herein, novel orexin antagonists with a spiro-type piperidine skeleton was designed and synthesized via removal of the unnecessary sites of orexin 1 receptor (OX1R) antagonists with a morphinan skeleton for binding to OX1R. In addition, while decahydroisoquinoline compounds with an A-ring did not show antagonistic activity for OX1R, spiro-type piperidine compounds with a dihydroindene structure showed antagonistic activities. This suggests that the lipophilic site corresponding to the A-ring of the morphinan skeleton is important for determining the antagonistic activity toward OX1R.
Heterocycles published new progress about Diastereoselective synthesis. 137419-24-0 belongs to class piperidines, name is tert-Butyl spiro[indene-1,4′-piperidine]-1′-carboxylate, and the molecular formula is C18H23NO2, Product Details of C18H23NO2.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem