Pencil graphite electrode modified with nitrogen-doped graphene and molecular imprinted polyacrylamide/sol-gel as an ultrasensitive electrochemical sensor for the determination of fexofenadine in biological media was written by Oghli, Abbas Hassan;Soleymanpour, Ahmad. And the article was included in Biochemical Engineering Journal in 2021.Recommanded Product: 83799-24-0 The following contents are mentioned in the article:
A sensitive and selective sensor was developed for the determination of fexofenadine (FEX) drug. The sensor was constructed based on the modification of a pencil graphite electrode (PGE) as a low cost, high available and versatile working electrode. The PGE was modified by nitrogen-doped graphene (NDG) and molecularly imprinted polymer (MIP) as receptor to increase the sensitivity and reducing the interference of other chems. NDG was electrochem. deposited on the electrode surface which is more homogeneous and facilitated than its conventional chem. synthesis. The mol. imprinted polymer was immobilized on the NDG layer by the sol-gel technique. In the optimum conditions, the imprinting factor was obtained equal to 4.8, indicating the optimal selectivity of the sensor for the determination of FEX. Differential pulse voltammetry (DPV) was used for the determination of FEX, which exhibited a linear calibration graph of Ip vs. FEX concentration in the range of 5.0 x 10-10-7.8 x 10-6 M (mol L-1). The detection limit of the sensor was calculated equal to 1.5 x 10-10 M, which displayed a superior detection limit when compared with the other electrochem. sensors reported for the FEX determination The developed sensor contained advantages of simple design, satisfactory reproducibility, appropriate determination recoveries and high selectivity. These features permitted the successful application of the sensor for the measurement of FEX in pharmaceutical and biol. samples. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Recommanded Product: 83799-24-0).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Recommanded Product: 83799-24-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem