Overcoming epithelial-mesenchymal transition-mediated drug resistance with monensin-based combined therapy in non-small cell lung cancer was written by Ochi, Kosuke;Suzawa, Ken;Tomida, Shuta;Shien, Kazuhiko;Takano, Jui;Miyauchi, Shunsaku;Takeda, Tatsuaki;Miura, Akihiro;Araki, Kota;Nakata, Kentaro;Yamamoto, Hiromasa;Okazaki, Mikio;Sugimoto, Seiichiro;Shien, Tadahiko;Yamane, Masaomi;Azuma, Kazuo;Okamoto, Yoshiharu;Toyooka, Shinichi. And the article was included in Biochemical and Biophysical Research Communications in 2020.Synthetic Route of C21H26N2S2 This article mentions the following:
The epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis and is also associated with drug resistance. Thus, controlling EMT status is a research of interest to conquer the malignant tumors. A drug repositioning anal. of transcriptomic data from a public cell line database identified monensin, a widely used in veterinary medicine, as a candidate EMT inhibitor that suppresses the conversion of the EMT phenotype. Using TGF-induced EMT cell line models, the effects of monensin on the EMT status and EMT-mediated drug resistance were assessed. Tgf treatment induced EMT in non-small cell lung cancer (NSCLC) cell lines and the EGFR-mutant NSCLC cell lines with TGF-induced EMT acquired resistance to EGFR-tyrosine kinase inhibitor. The addition of monensin effectively suppressed the TGF-induced-EMT conversion, and restored the growth inhibition and the induction of apoptosis by the EGFR-tyrosine kinase inhibitor. Our data suggested that combined therapy with monensin might be a useful strategy for preventing EMT-mediated acquired drug resistance. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Synthetic Route of C21H26N2S2).
10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Synthetic Route of C21H26N2S2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem