Recently I am researching about CATALYZED HYDROAMINATION; INTERNAL ALKYNES; H BONDS; CARBOAMINATION; ALKENES; GENERATION; ACID; HETEROCYCLES; CYCLIZATION; INSERTION, Saw an article supported by the Hong Kong Research Grants CouncilHong Kong Research Grants Council [PolyU 153031/14P, PolyU11/CRF/13E]; State Key Laboratory of Chemical Biology and Drug Discovery; Hong Kong Polytechnic UniversityHong Kong Polytechnic University [G-YBM8]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Cui, JF; Tang, RS; Yang, B; Lai, NCH; Jiang, JJ; Deng, JR; Wong, MK. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane
This work first discloses a new strategy for amine activation to give reactive amine anion by in situ generated iminium cation-amine anion pair through decomposition of sterically hindered aminals. Utilizing this strategy, a highly regio- and chemoselective cyclocarboamination of ortho-formyl phenylacetylenes with secondary amines has been realized under metal-free mild reaction conditions. The cyclocarboamination with notably tunable product profiles depends on the separation and purification procedure, a diverse range of 1, 3-diamino-1H-indenes (essentially reactive enamines) and 3-amino-1-indanones were obtained, respectively. Moreover, using iodine as an electrophile to couple with various ortho-formyl phenylacetylenes and secondary amines, a series of 3-amino-2-iodo-1-indanones were efficiently achieved with four bonds (C=O, C-C, C-N and C-I) formation in an one-pot three-component reaction. These results demonstrated an unprecedented methodology for the construction of highly functionalized 1H-indene and 1-indanone compounds.
About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Cui, JF; Tang, RS; Yang, B; Lai, NCH; Jiang, JJ; Deng, JR; Wong, MK or concate me.. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem