Application of 120013-39-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 120013-39-0, Name is 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride, SMILES is Cl.COC2=C(C=C1C(C(CC1=C2)CC3CCNCC3)=O)OC, belongs to piperidines compound. In a article, author is Rehman, Aziz-ur, introduce new discover of the category.
Synthesis of new heterocyclic 3-piperidinyl-1,3,4-oxadiazole derivatives as potential drug candidate for the treatment of Alzheimer’s disease
A series of new N-substituted derivatives of 3-[(5-{1-[(4-chlorophenyl) sulfonyl]- 3-piperidinyl}-1,3,4-oxadiazol-2-yl) sulfanyl] propanamide (7a-q) was synthesized to evaluate new drug candidates for Alzheimer’s disease. 4-Chlorobenzenesulfonyl chloride (a) and ethyl piperidin-3-carboxylate (b) were converted into 5-{1-[(4-chlorophenyl) sulfonyl]- 3-piperidinyl}-1,3,4-oxadiazol-2-thiol (3) through a series of three steps. A series of electrophiles, N-alkyl/aralkyl/aryl-3-bromopropanamide (6a-q), was synthesized by gearing up 3-bromopropionyl chloride (5) with different alkyl/aralkyl/aryl amines (4a-q). Target compounds were synthesized by reacting compound 3 with different electrophiles, 6a-q, under basic conditions in an aprotic polar solvent. The synthesized compounds were subjected to spectral analysis, EI-MS, IR, H-1-NMR and C-13-NMR, for structural elucidation. The compounds were screened for enzyme inhibition activity against acetyl cholinesterase (AChE) enzyme. The validity of synthesized compounds as new drug candidates was also evaluated through haemolytic activity.
Application of 120013-39-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 120013-39-0.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem