Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Lim, Ngiap-Kie, once mentioned the application of 14691-89-5, Name is 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl, molecular formula is C11H21N2O2*, molecular weight is 213.3, MDL number is MFCD00043593, category is piperidines. Now introduce a scientific discovery about this category, Computed Properties of C11H21N2O2*.
A fit for purpose synthesis of Bruton’s tyrosine kinase inhibitor GDC-0852
The development of an expedient synthesis to GDC-0852 (1), a reversible BTK inhibitor drug candidate, is described. The key starting material tricyclic lactam 5 was prepared by an annulation reaction of unprotected piperidine-2-carbaldehyde HCl salt (20) and N-Boc piperidine-2,4-dione 21 in a safe and scalable manner. A highly selective Pd-catalyzed C-N coupling of lactam 5 and linker 2a, followed by Suzuki-Miyaura coupling to fragment 8 subsequently provided a direct and convergent access to the penultimate 17. A simple NaBH4 aldehyde reduction completed the synthesis to GDC-0852 (1) in high yield (54% over 3 steps from 5) and purity (99.0 A% HPLC). (C) 2020 Elsevier Ltd. All rights reserved.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 14691-89-5, Computed Properties of C11H21N2O2*.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem