Electric Literature of 13360-65-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 13360-65-1, Name is 3-Ethyl-2,5-dimethylpyrazine, SMILES is CC1=CN=C(C)C(CC)=N1, belongs to piperidines compound. In a article, author is Wachtendorf, Daniel, introduce new discover of the category.
Octahydrocyclopenta[c]pyridine Scaffold – Enantioselective Synthesis and Indole Annulation
An optically active hexahydrocyclopenta[c]pyridine derivative with quaternary stereocenter was prepared as a new heterocyclic scaffold. Key reaction was the Pd-catalyzed asymmetric allylic alkylation of a piperidine-based beta-oxoester, which proceeded in very good yield with high level of enantioselectivity (90 %, 95 % ee). The a-allyl moiety was transformed into a 1,4-diketone by Pd-catalyzed Wacker oxidation with molecular oxygen (89 %). This intermediate was cyclized in an intramolecular aldol reaction furnishing the cyclopentenone motif (86 %). Hydrogenation of the C-C double bond gave the cisannulated octahydrocyclopenta[c]pyridine (86 %), which was submitted to Fischer indolization (85 %). Although two regioisomers could be expected, only the angular constitution was observed. Relative and absolute configurations were established by X-ray crystallography of a para-iodo benzamide derivative. The utility of the title compound as scaffold is further highlighted by a number of synthetically useful transformations, for instance formation of carboxamides, sulfonamides, ureas and reductive aminations with aldehydes.
Electric Literature of 13360-65-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 13360-65-1.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem