Nomoto, Yuji; Obase, Hiroyuki; Takai, Haruki; Hirata, Tadashi; Teranishi, Masayuki; Nakamura, Joji; Kubo, Kazuhiro published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Studies on cardiotonic agents. I. Synthesis of some quinazoline derivatives》.Electric Literature of C13H16N2O The author mentioned the following in the article:
A series of quinazoline derivatives with various 4-heterocyclylpiperidino groups at the 4-position was synthesized and tested for cardiotonic activity in anesthetized dogs. E.g., reaction of 6-acetamido-4-chloro-7-methoxyqinazoline and 4-(2-oxo-1-imidazolidinyl)piperidine gave quinazoline derivative I. Among them, several 6,7-dimethoxyquinazoline derivatives showed potent cardiotonic activity. In the part of experimental materials, we found many familiar compounds, such as 3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1Electric Literature of C13H16N2O)
3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Electric Literature of C13H16N2O
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem