Nirogi, Ramakrishna et al. published their research in European Journal of Medicinal Chemistry in 2015 | CAS: 189442-87-3

Ethyl N-Boc-4-methylpiperidine-4-carboxylate (cas: 189442-87-3) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: Ethyl N-Boc-4-methylpiperidine-4-carboxylate

Synthesis and SAR of Imidazo[1,5-a]pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer’s disease was written by Nirogi, Ramakrishna;Mohammed, Abdul Rasheed;Shinde, Anil K.;Bogaraju, Narsimha;Gagginapalli, Shankar Reddy;Ravella, Srinivasa Rao;Kota, Laxman;Bhyrapuneni, Gopinadh;Muddana, Nageswara Rao;Benade, Vijay;Palacharla, Raghava Chowdary;Jayarajan, Pradeep;Subramanian, Ramkumar;Goyal, Vinod Kumar. And the article was included in European Journal of Medicinal Chemistry in 2015.Recommanded Product: Ethyl N-Boc-4-methylpiperidine-4-carboxylate This article mentions the following:

Alzheimer’s disease (AD) is a neurodegenerative disease which has a higher prevalence and incidence in older people. The need for improved AD therapies is unmet. The 5-hydroxytryptamine4 receptor (5-HT4R) partial agonists may be of benefit for both the symptomatic and disease-modifying treatment of cognitive disorders associated with AD. Herein, we report the design, synthesis and SAR of imidazo[1,5-a] pyridine derivatives as 5-HT4R partial agonists. The focused SAR, optimization of ADME properties resulted the discovery of compound I as potent, selective, brain penetrant 5-HT4 partial agonist as a lead compound with good ADME properties and efficacy in both symptomatic and disease modifying animal models of cognition. In the experiment, the researchers used many compounds, for example, Ethyl N-Boc-4-methylpiperidine-4-carboxylate (cas: 189442-87-3Recommanded Product: Ethyl N-Boc-4-methylpiperidine-4-carboxylate).

Ethyl N-Boc-4-methylpiperidine-4-carboxylate (cas: 189442-87-3) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: Ethyl N-Boc-4-methylpiperidine-4-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem