With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98977-36-7,1-Boc-3-Piperidinone,as a common compound, the synthetic route is as follows.,98977-36-7
Potassium tert-butoxide (0.971 g),A mixture of tetrahydrofuran (25 mL) and methyltriphenylphosphonium iodide (3.50 g, CAS number: 2065-66-9) was stirred at room temperature for 1 hour. Tert-butyl 3-oxopiperidine-1-carboxylate (1.50 g,A solution of CAS number: 98977-36-7) in tetrahydrofuran (15 mL) was added dropwise, and the mixture was stirred at room temperature overnight. After adding a saturated aqueous solution of ammonium chloride to the reaction solution, the reaction mixture was extracted with ethyl acetate.The organic layer was washed with saturated saline and dried over anhydrous sodium sulfate.After filtration and concentration under reduced pressure, the obtained residue was subjected to silica gel column chromatography (n-hexane / ethyl acetate) to give the title compound (0.994 g) as an oil.
The synthetic route of 98977-36-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Daiichi Sankyo Healthcare Co Ltd; Naito, Hiroyuki; Suzuki, Takayuki; Murata, Takeshi; Kawai, Junya; Higuchi, Saito; (99 pag.)JP2020/45306; (2020); A;,
Piperidine – Wikipedia
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