With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-53-3,1-N-Boc-3-Cyanopiperidine,as a common compound, the synthetic route is as follows.
91419-53-3, Step 4. Piperidine-3-carbonitrile hydrochloride; A 250-mL 3-necked round-bottomed flask was charged with tert-butyl 3-cyanopiperidine-1-carboxylate (5.8 g, 27.07 mmol, 1.00 equiv, 98%) in 1,4-dioxane (60 mL). The mixture was cooled down to at 0 C. and treated with HCl (g). The mixture was stirred for 2 hours at 0 C. resulting in a precipitate that was collected by filtration to afford piperidine-3-carbonitrile hydrochloride as white solid (1.9 g, 48%).
91419-53-3 1-N-Boc-3-Cyanopiperidine 2756785, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; Kalypsys, Inc; US8080566; (2011); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem