With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.887354-02-1,(3-Chlorophenyl)(piperidin-4-yl)methanone,as a common compound, the synthetic route is as follows.
887354-02-1, iii) (S)-5-[4-(3-Chloro-benzoyl)-piperidin-1-yl]-4-({5-[2-((S)-2-cyclobutylcarbamoyl- pyrrolidin-1 -yl)-2-oxo-ethoxy]-1 -phenyl-1 H-pyrazole-3-carbonyl}-amino)-5-oxo- pentanoic acid; To a solution of 150 mg (S)-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo- ethoxy]-1 -phenyl-1 H-pyrazole-3-carbonyl}-amino)-pentanedioic acid 5-tert-butyl ester in 7 ml DMF were added 62 mul DIPEA, 95 mg HATU and 56 mg 4-(3-chlorobenzoyl)-piperidine. After stirring for 12 h saturated NaHCC>3 solution was added and the mixture loaded on a chem elut cartridge, the crude product being eluted with dichloromethane. The solution was concentrated to a volume of 1 ml and stirred in the presence of 100 mul TFA. After stirring for 4 h the solvents were removed under reduced pressure and the residue purified by preparative HPLC (C18 reverse phase column, elution with a water/MeCN gradient with 0.1 % TFA). The fractions containing the product were lyophilized to yield the pure product. Yield: 135 mg MS(ES+): m/e = 747.
887354-02-1 (3-Chlorophenyl)(piperidin-4-yl)methanone 3645096, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; SANOFIS-AVENTIS; WO2009/80226; (2009); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem