With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.885279-92-5,1-Boc-1,8-diaza-spiro[4.5]decane,as a common compound, the synthetic route is as follows.
8-Benzyl 1-fetaut-butyl L8-diazaspiror4.5″|decane-l,8-dicarboxylate (C-I); To a solution of 5.0 g (20.8 mmol) A-S in 200 mL CH2Cl2 cooled to 00C was added 7.3 mL (41.6 mmol) DIPEA and 3.1 mL (21.8 mmol) benzyl chloroformate. After 30 minutes, the cooling bath was removed and the reaction was stirred at room temperature for 3 h before being dumped into 0.5 M HCl in a separatory funnel. The layers were separated, the aqueous layer was extracted once with CH2Cl2, the combined organic layers were washed again with 0.5M HCl, then with saturated aqueous NaHCO3, water, dried over Na2SO4, and concentrated by rotary evaporation. The residue was purified by column chromatography on silica gel (EtOAc/hexanes) to provide C-I as a white solid. Data for C-I: LC/MS: rt = 2. 73 min; m/z (M + H) = 375.1, found; 375.2 required., 885279-92-5
885279-92-5 1-Boc-1,8-diaza-spiro[4.5]decane 34178602, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; MERCK & CO., INC.; WO2007/25069; (2007); A2;,
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