New learning discoveries about 883984-95-0

883984-95-0 Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate 59165781, apiperidines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883984-95-0,Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate,as a common compound, the synthetic route is as follows.

INTERMEDIATE 16 r-(Methoxymethvnspirorpiperidine-4.4′-pyrido[2.3-(iiri.31oxazinl-2riy)-one Step A. Benzyl 7′-chloro-l’-(‘methoxymethyl)-2′-oxo-r,2′-dihvdro-lH-spiro[piperidme-4,4’- pyridor2.3-lithium bis(trimethylsilyl)amide (2.86 niL of IM solution, 2.86 mmol) followed by chloromethyl methyl ether (0.094 mL, 1.01 mmol). After 0.5 h, the reaction was diluted with EtOAc, extracted with water (3x) and brine, dried over MgSO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography, eluting with a gradient of 0 to 20% ethyl acetate : dichloromethane to give the title compound (0.21 g). MS 432.1 (M + 1)., 883984-95-0

883984-95-0 Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate 59165781, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK & CO., INC.; WO2006/44504; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem