With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85908-96-9,N-Boc-2-Piperidone,as a common compound, the synthetic route is as follows.,85908-96-9
Lithium bis(trimethylsilyl)amide (11.1 mL of a 1 M solution in THF, 11.1 mmol) was slowly added at 78 C underan argon atmosphere to a solution of lactam 1b (1.0 g, 5.05 mmol) in anhydrous THF (100 mL), and thesolution was stirred for 1 h. Then, ethyl chloroformate (532 l, 5.56 mmol) and, after 1 h of continuousstirring at 78 C, a solution of PhSeCl (1.48 g, 7.58 mmol) in anhydrous THF (10 mL) were addedto the solution. The mixture was stirred for a further 1 h and poured into saturated aqueous NH4Cl.The resulting mixture was extracted with EtOAc, and the combined organic extracts were dried,filtered, and concentrated under reduced pressure. Flash chromatography (8:2 hexane-EtOAc) of theresulting oil gave the seleno derivative 7 (1.79 g, 83% yield) as a yellow foam: IR (ATR Pike) (cm1):1718 (CO); 1H-NMR (300 MHz, CDCl3): d = 1.27 (t, J = 7.2 Hz, 3H, CH2CH3), 1.54 [s, 9H, (CH3)3C], 1.73(m, 1H, H-5), 1.84 (m, 1H, H-5), 2.01 (ddd, J = 13.8, 10.2, 5.7 Hz, 1H, H-4), 2.28 (dt, J = 13.8, 6.0 Hz, 1H,H-4), 3.52 (m, 1H, H-6), 3.61 (ddd, J = 13.2, 8.4, 5.4 Hz, 1H, H-6), 4.22 (qd, J = 7.2, 3.3 Hz, 2H, CH2CH3),7.31 (t, J = 7.2, 2H, HAR), 7.41 (t, J = 7.2 Hz, 1H, HAR), 7.65 (t, J = 7.2 Hz, 2H, HAR); HRMS (ESI) calcdfor [C19H25NO5Se + Na+]: 450.0787, found: 450.0788.
85908-96-9 N-Boc-2-Piperidone 7577838, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Arioli, Federica; Perez, Maria; Are, Celeste; Molins, Elies; Bosch, Joan; Amat, Mercedes; Molecules; vol. 24; 3; (2019);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem