With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85908-96-9,N-Boc-2-Piperidone,as a common compound, the synthetic route is as follows.
85908-96-9, General procedure: To a solution of compounds 15, 16, 17 (2 mmol) and diphenyl phosphoryl chloride (0.62 mL, 3 mmol) in anhydrous THF (30 mL) cooled at -78 C and under nitrogen atmosphere, was added dropwise with stirring a solution of KHMDS (6 mL, 0.5 M in toluene, 3 mmol). After 30 min at -78 C, water (20 mL) was added and the resulting mixture was extracted with Et2O (2 × 50 mL) and dried over MgSO4. Evaporation of the solvent under vacuum yielded the vinyl phosphates as yellow oils, which were used directly in the next coupling step.
85908-96-9 N-Boc-2-Piperidone 7577838, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Sallio, Romain; Lebrun, Stephane; Agbossou-Niedercorn, Francine; Michon, Christophe; Deniau, Eric; Tetrahedron Asymmetry; vol. 23; 13; (2012); p. 998 – 1004;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem