With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.
79099-07-3, Trimethylsulfoxonium iodide (13.3 grams, 0.06 mole) was added to a stirred solution of sodium hydride (60 % dispersion in oil, 3.0 grams, 0.126 mole) in THF (150 mL) at 10 C. Reaction mass temperature was slowly raised to RT and stirred further for 2 hours at the same temperature. Reaction mass, was then cooled to 10 C and added M-boc-piperidine-4-one (10 grams, 0.05 mole) solution in THF (50 mL) at the same temperature. Then reaction mass temperature was slowly raised to RT and stirred for 3 hours at same temperature. The progress of the reaction was monitored by. TLC. After completion of the reaction (TLC), the mass was quenched in chilled water (300 mL), the compound was extracted with dichloromethane (3 x 150 mL). The combined organic phase was washed with water (100 mL), brine solution (100 mL) and dried over sodium sulphate. The organic phase was concentrated on rotavacuum to obtain the crude residue, which was further purified by flash chromatography using ethyl acetate: n-hexane ( 15:85) to afford the title compound. Yield: 7.1 grams (66 %). – N R (6 ppm): 1.47 (9H, s), 1.59 – 1.62 (2H. m), 1.76 – 1.83 (2H, m).2.69 (2H, s), 3.39 – 3.45 (2H,m), 3.70 -3.73 (2H, m); Mass(m/z): 158.2 (M-56)+.
79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; SHINDE, Anil Karbhari; JASTI, Venkateswarlu; WO2014/147636; (2014); A1;,
Piperidine – Wikipedia
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