With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.,79099-07-3
Prepared according to a variation of a literature procedure (J. Med. Chem., 2008, 51 , p2170): Trimethylsulfoxonium iodide (22.5 g, 102 mmol) was suspended in DME (100 mL) under N2 and potassium fe/f-butoxide (12.5 g, 1 1 1 mmol) was added. After 30 min, the mixture was cooled to 0 C and a solution of fe/f-butyl 4-oxopiperidine-1-carboxylate (20 g, 100 mmol) in DME (20 mL) was added dropwise over 45 min. The reaction was allowed to warm to RT over 16 h then quenched by the addition of water (150 mL). The mixture was extracted with Et20 (3 x 100 mL). The combined organic extracts were washed with brine (100 mL), dried over MgS04 and concentrated. The residue was dried by azeotropic distillation with toluene to give the title compound (16.5 g, 83%). 1 H NMR (300 MHz, CDCI3): delta 3.81-3.58 (m, 2H), 3.40 (ddd, 2H), 2.67 (s, 2H), 1.78 (ddd, 2H), 1.56-1.30 (m, 2H), 1.45 (s, 9H).
79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; ALMAC DISCOVERY LIMITED; HEWITT, Peter; MCFARLAND, Mary Melissa; ROUNTREE, James Samuel Shane; BURKAMP, Frank; BELL, Christina; PROCTOR, Lauren; HELM, Matthew Duncan; O’DOWD, Colin; HARRISON, Timothy; (280 pag.)WO2018/20242; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem