79099-07-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.
To a stirred solution of tert-butyl 4-oxopiperidine-l-carboxylate (step 1, 6.0 g, 30.15 mmol, 1.0 eq) in DCM (60 mL) was added diethylaminosulfmtrifiuoride (DAST) (5.97 mL, 45.22 mmol, 1.5 eq) at 0 C. The reaction mixture was stirred at same temperature for about 6 hours. TLC indicated starting material was consumed and the desired product was observed. The reaction mixture was poured into ice cold water and extracted with DCM. The organic layer was washed with water, brine solution and the organic layer was dried with Na2S04. The filtrate was concentrated to get the crude residue which was purified by column chromatography by using 10% EtOAc and hexane as an eluent to obtain the desired product (6.0 g, yield: 90.0%) as a white solid. 1H NMR (DMSO-d6, 300 MHz): delta 3.45-3.41 (m, 4H), 1.98-1.85 (m, 4H) and 1.40 (s, 9H); Mass: [M+H]+222.53 (20%).
The synthetic route of 79099-07-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HETERO LABS LIMITED; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; MUKKERA, Venkati; NEELA, Sudhakar; (77 pag.)WO2017/149518; (2017); A1;,
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