79099-07-3, 1-Boc-4-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,79099-07-3
Step-1: 3,3-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester; Methyl iodide (11.8 ml, 0.19 mol) was added at 0 C. to a solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (18 g, 0.09 mol). Sodium tert butoxide (20.9 g, 0.22 mol) was then added at 0 C. and the resulting mixture was heated to reflux for 1 hour. The reaction mixture was concentrated under reduced pressure, diluted with water and the product was extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate and concentrated Purification of the residue by column chromatography (2% ethyl acetate-hexane) afforded 7 g (37%) of 3,3-dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester. 1H-NMR (400 MHz, CDCl3) delta (ppm): 3.7 (m, 2H), 3.41 (m, 2H), 2.47 (t, 2H), 1.48 (s, 9H), 1.09 (s, 6H).
79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; KHAMRAI, Uttam; Ronsheim, Matthew; Karak, Sumit Kumar; US2010/152160; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem