With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.
A stirred solution of 60percent aqueous sodium hydroxide solution (117 mg, 2.92 mmol) in dimethyl sulfoxide (2 ml) was added with trimethyl sulfoxinium iodide (627 mg, 2.79 mmol) under a nitrogen atmosphere. The mixture was stirred for 45 minutes in ice-water bath, added slowly with 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 2.5 mmol) while maintaining the temperature below 10¡ã C. Upon completion of the addition, the mixture was stirred for 5 minutes in the ice-water bath and stirred for another 2 hours at 25¡ã C. in an oil bath. The resulting mixture was added with cold water (20 ml) and extracted with ethyl ether (20 ml.x.3). The combined organic extracts were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 1-oxa-6-aza-spiro[2.5]octane-6-carboxylic acid tert-butyl ester (479 mg, 85.5percent) as a white solid.MS m/z (ESI): 213 [M+1]
79099-07-3 1-Boc-4-Piperidone 735900, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; Tang, Peng Cho; Su, Yidong; Zhang, Lei; Xiao, Lu; US2010/4239; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem