78190-11-1, 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1: To the corresponding Cbz-protected product from general procedure G, step D (323 mg, 0.441 mmol), N-cbz-piperidin-3-ylcarboxylic acid (370 mg, 1.405 mmol), and TBTU (450 mg, 1.400 mmol) in THF (15 ml) is added at room temperature N-ethyldiisopropylamine (0.3 ml, 1.718 mmol) and the mixture is stirred at room temperature overnight and then heated to reflux for 8 h. Sat. aq. sodium bicarbonate (40 ml) is added, the mixture stirred for 15 min., and then extracted with ether (3 x 70 ml). The combined org. layers are dried over sodium sulfate, concentrated in vacuo, and the residue purified by flash chromatography (silica, dichloromethane/MeOH 20:1) to give a mixture of the 2 diastereoisomeric bis-Cbz-protected intermediates. Flash chromatography (silica, ethyl acetate/MeOH 100:0 – 50:1) afforded the 2 diastereoisomers (23 % and 16 %). ESI-MS: (M+H)+ = 942. Step 2: The 2-Cbz-protected diastereoisomers are submitted separately to hydrogenation in MeOH (20 ml) at 50 psi in the presence of Pd/C (10 %) at 50 C for 2 h. The catalyst is removed by filtration and the filtrate is concentrated in vacuo to give the product (41 % and 35 %). ESI-MS: (M+H)+ = 674
78190-11-1, As the paragraph descriping shows that 78190-11-1 is playing an increasingly important role.
Reference：
Patent; NOVO NORDISK A/S; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2004/48345; (2004); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem