710972-40-0, tert-Butyl 4-((2-methoxyethyl)amino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
tert-Butyl 4-[(2-methoxyethyl)amino]piperid me-i -carboxylate (300 mg, 1 .16 mmol) wasdissolved in THF (10 mL) and treated with N-methyl-2-pyrrolidinone (344 mg, 3.48 mmol) andtriethylamine (0.7 mL, 4.65 mmol). The reaction mixture was stirred at 70 C for 1 h, then Intermediate 108, 2,2,2-trifluoroethyl trifluoromethanesulfonate (297 mg, 1.28 mmol) was added dropwise at 25 C. The resulting reaction mixture was stirred at 70 C for 16 h. The solvents were removed in vacuo and the reaction mixture was partitioned between H20 (120mL) and EtOAc (100 mL). The aqueous layer was further extracted with EtOAc (2 x 100 mL), and the combined organic layers were dried (Na2SO4). The solvent was removed in vacuo and residue was purified by column chromatography (Normal neutral activated alumina, at 10 % to20 % EtOAc in hexane) to give tert-butyl 4-[(2-methoxyethyl)(2,2,2-trifluoroethyl)amino]piperidine-1-carboxylate (180 mg, 46 %) as a gum. LCMS (Method I): mlz 341 (M+H) (ES), at 5.31 mi UV active., 710972-40-0
710972-40-0 tert-Butyl 4-((2-methoxyethyl)amino)piperidine-1-carboxylate 43652134, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; HEPTARES THERAPEUTICS LIMITED; BROWN, Giles Albert; CONGREVE, Miles Stuart; PICKWORTH, Mark; TEHAN, Benjamin Gerald; (117 pag.)WO2017/21730; (2017); A1;,
Piperidine – Wikipedia
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