With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.625471-18-3,(S)-tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
625471-18-3, 1, 1-Dimethylethyl-(3S)-3-aminopiperidine-1-carboxylate (2g, 11mmol), 4H- tetrahydropyran-4-one (1. lg, llmmol) and dichloroethane (40mL) were stirred under nitrogen at room temperature for 15 min. Sodium triacetoxyborohydride (2.9g, 14mmol) was added in 3 lots over 30 minutes and stirred overnight. The reaction was diluted with water (50mL) and made basic by addition of 2N NaOH solution. After stirring for lh, the mixture was extracted into dichloromethane, and the combined organic extracts washed with brine, dried (MgSO4), filtered and evaporated in vacuo to give the title compound as an oil
The synthetic route of 625471-18-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/60949; (2005); A2;,
Piperidine – Wikipedia
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