With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61995-20-8,Benzyl 3-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
crude purified product (770 mg) of benzyl 3-oxopiperidine-1-carboxylate, 2,2-dimethylpropan-1-amine (643 mg) and acetic acid (0.5 mL) were dissolved in THF (10 mL), and sodium triacetoxyborohydride (1563 mg) was added at room temperature. The mixture was stirred at room temperature for 1 hr, to the reaction mixture was added water at room temperature, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was dissolved in THF (10 mL), di-tert-butyl dicarbonate (1610 mg) and triethylamine (2.57 mL) were added at room temperature, and the mixture was stirred at 60 C. for 6 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (690 mg) as a colorless oil. (1235) 1H NMR (300 MHz, CDCl3) delta 0.89 (9H, brs), 1.31-1.53 (10H, m), 1.66-1.95 (2H, m), 2.10-3.82 (6H, m), 3.99-4.27 (2H, m), 4.99-5.22 (2H, m), 7.28-7.41 (5H, m)., 61995-20-8
The synthetic route of 61995-20-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; AIDA, Jumpei; YOSHITOMI, Yayoi; HITOMI, Yuko; NOGUCHI, Naoyoshi; HIRATA, Yasuhiro; FURUKAWA, Hideki; SHIBUYA, Akito; WATANABE, Koji; MIYAMOTO, Yasufumi; OKAWA, Tomohiro; TAKAKURA, Nobuyuki; MIWATASHI, Seiji; (199 pag.)US2016/115128; (2016); A1;,
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