5773-58-0, 3-Methylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5773-58-0
3-Methylpiperidin-4-one (1.34 g, 11.9 mmol) was dissolved in dichloromethane (30 ml), Et3N (6.12 ml) was added followed by 4-chlorobenzyl bromide (2.46 g, 12 mmol) and the reaction mixture was stirred at room temperature over night, partitioned between dichloromethane and water. The organic layer was dried over Na2SO4, filtered and the filtrate was concentrated in vacuo. The residue was dissolved in pyridine (30 ml), NH2OH HCl (1.53 g) was added and the mixture was stirred at room temperature over night, partitioned between ethyl acetate and water. The organic layer was washed with water, dried over Na2SO4, filtered and the filtrate was concentrated in vacuo to give l-(4- chlorobenzyl)-3-methylpiperidin-4-one-oxime (2.1 g). 1H-NMR (CDCl3, 400 MHz): 58.39 (br.s, IH); 7.28 (s, 4H); 3.47 (m, 2H); 3.00 (m, IH); 2.77 (m, 2H); 2.58 (m, IH); 2.26 (m, 2H); 2.05 (dd, J= 9.2, 11.0 Hz, IH); 1.08 (d, J= 6.6 Hz, 3H). APCI-MS : m/z 253 (MH+).
5773-58-0 3-Methylpiperidin-4-one 12284277, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; ASTRAZENECA AB; WO2007/53082; (2007); A1;,
Piperidine – Wikipedia
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