555-92-0, (S)-2-Propylpiperidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred suspension of LiAlH4 (500 mg, 166 mmol) in dry ether (20 mL) cooled in an ice-bath was added dropwise a solution of the lactam 26 (500 mg, 3.54 mmol) in dry ether (2e3 mL). The reaction mixture was then refluxed for 4 h. After cooling in an ice-bath, excess LiAlH4 was quenched with sequential addition of water (3 mL), 10% NaOH solution (3 mL). The reaction mixture was stirred at room temperature for 2e3 h for hydrolysis and the aluminum residues were removed by filtration. The filtrate was dried over anhydrous Na2SO4, then anhydrous HCl solution (3e5 mL) in ether was added dropwise. Evaporation of volatiles in vacuo gave the crude solid hydrochloride salt (550 mg, 97%). To a solution of the coniine hydrochloride salt (500 mg, 3.16 mmol) in H2O (15 mL) was added solid NaHCO3 (1.86 g, 22.1 mmol), then (Boc)2O (850 mg, 3.9 mmol). After stirring the reaction mixture at room temperature overnight, %10 NaOH solution (3 mL) was added and stirring continued for additional 2 h. The product was extracted with ether (2 50 mL), then washed brine (2 50 mL) and dried (Na2SO4). Evaporation of volatiles in vacuo and purification by flash column chromatography eluting with the ((ether/ hexane) 1:20) solvent system afforded N-Boc coniine (560 mg, 82) as a clear oil. ?a 30 D th32.6 (c 1, CHCl3), lit.29k ?a 25 D th33.5 (c 0.6, CHCl3), TLC, Rf 0.18 [(ether/hexane) 1:20]; 1H NMR (400 MHz, CDCl3) d 0.92 (3H, t, J?7.0), 1.22e1.41 (4H, m), 1.45 (9H, s), 1.51e1.70 (6H, m), 2.71e2.78 (1H, m), 3.96 (1H, d, br, J?13.0), 4.21 (1H, m).
555-92-0, 555-92-0 (S)-2-Propylpiperidine hydrochloride 12303861, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Karanfil, Abdullah; Balta, Berrin; Eskici, Mustafa; Tetrahedron; vol. 68; 49; (2012); p. 10218 – 10229,12;; ; Article; Karanfil, Abdullah; Balta, Berrin; Eskici, Mustafa; Tetrahedron; vol. 68; 49; (2012); p. 10218 – 10229;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem