53617-36-0,53617-36-0, 1-Methyl-4-(piperidin-4-yl)piperazine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 72; 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide; A suspension is prepared of 350 mg (1.06 mM) of acid obtained according to preparation III in 3 ml of DCM and 243 mg (1.27 mM) of EDCI (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and 173 mg (1.27 mM) of HOAT, are added. The mixture is agitated for 30 min at ambient temperature, and 232 mg (1.27 mM) of 1-methyl-4-(4-piperidinyl)piperazine are then added. The reaction mixture is agitated for 18 hours at ambient temperature and is then poured over 10 ml of water and extracted with DCM. The organic phase is washed with water, dried and concentrated under reduced pressure. The residue is purified by silica gel chromatography in eluting with the aid of a DCM/methanol mixture (90/10; v/v). 449 mg of the product sought after are thus obtained as a yellow oil (yield=86percent). 1H NMR (300 MHz, CD3CN) delta: 6.74 (s, 2H); 4.35 (d, 1H); 4.01 (q, 2H); 3.81 (s, 3H); 3.69 (d, 1H); 3.56 (t, 2H); 3.26 (t, 2H); 2.89 (t, 1H); 2.75 (s, 3H); 2.58 (s, 6H); 2.40 (m, 10H); 2.17 (s, 3H); 1.75 (m, 2H); 1.27 (m, 2H).
53617-36-0 1-Methyl-4-(piperidin-4-yl)piperazine 795707, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Laboratoires Fournier S.A.; US2006/178360; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem