With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4876-59-9,4-(Dimethylamino)piperidine dihydrochloride,as a common compound, the synthetic route is as follows.
Dimethyl-piperidin-4-yl-amine dihydrochloride (Aldrich, 2.0 g, 9.95 mmol) and 4-fluoro-nitrobenzene (Aldrich, 2.5 g, 17.7 mmol) were added to methanol (30 mL). The mixture was heated to 90 C. and stirred for 3.5 hours. The mixture was treated with 1 N HCl to pH=1 and then extracted with diethyl ether (2*10 mL). The aqueous layer was treated with saturated sodium carbonate to pH=10 and then extracted with methylene chloride (2*20 mL). The organic layer was dried with sodium sulfate and the solvent was removed to give the desired product. 1.25 g, 50%. MS (m+H)+: 250.
4876-59-9, 4876-59-9 4-(Dimethylamino)piperidine dihydrochloride 22591440, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; Ding, Qingjie; Jiang, Nan; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; US2005/239843; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem