3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 7 4-Methyl-1-[3-[3-(trifluoromethyl)phenyl]sulfonyl-8-quinolyl]piperidin-4-ol Hydrochloride 4-Methylpiperidin-4-ol (292 mg, 2.53 mmol), 8-fluoro-3-(3-(trifluoromethyl)phenyl-sulfonyl)quinoline (200 mg, 0.563 mmol) and K2CO3 (311 mg, 2.252 mmol) were suspended in NMP (2 ml) and stirred in the Microwave at 225 C. for 35 min. The reaction mixture was diluted with ethyl acetate and washed 4* with water, dried and concentrated. The product was obtained by preparative HPLC chromatography on a reversed phase column. Finally the HCl salt was formed by adding one equivalent HCl to give 4-methyl-1-(3-(3-(trifluoromethyl)phenylsulfonyl)quinolin-8-yl)piperidin-4-ol hydrochloride (97 mg, yield 35.4%). LCMS (ESI+) m/z [M+H]+: 451.10 1H NMR (DMSO-d6, 500 MHz): delta=9.56 (d, J=2.1 Hz, 1H), 9.44 (d, J=2.1 Hz, 1H), 8.43-8.53 (m, 3H), 8.32 (d, J=8.2 Hz, 1H), 8.17 (d, J=7.9 Hz, 1H), 7.97 (t, J=7.9 Hz, 1H), 7.91 (t, J=7.9 Hz, 1H), 5.32-5.41 (m, broad, 1H), 4.04 (br s, 2H), 3.63 (s, 1H), 3.61 (s, 1H), 2.21 (m, 2H), 1.83 (m, 2H), 1.31 ppm (s, 3H)., 3970-68-1
The synthetic route of 3970-68-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Abbvie Deutschland GmbH & Co. KG; GENESTE, Herve; HAUPT, Andreas; POHLKI, Frauke; RELO, Ana Lucia; UNGER, Liliane; WICKE, Karsten; (53 pag.)US2017/260158; (2017); A1;,
Piperidine – Wikipedia
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