373604-28-5, tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1: Sodium hydride (40 mg, 1.0 mmol) was added to a 0C solution of tert-butyl 3-fluoro-4- hydroxypiperidine-1-carboxylate (200 mg, 0.9 12 mmol) in DMF (3.0 mL). The reaction mixture was stirred at 0C for 5 minutes, and then iodomethane (63 jiL, 1.0 mmol) was added. The mixture was slowly warmed to room temperature and stirred for 16 h. The mixture was dilutedwith EtOAc and washed with water and then brine. The organic layer was dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by colunm chromatography on silica gel (0 – 70% EtOAc/Hexanes) to afford tert-butyl 3-fluoro-4- methoxypiperidine-1-carboxylate as an oil.
373604-28-5, As the paragraph descriping shows that 373604-28-5 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; FISCHER, Christian; BOGEN, Stephane, L.; CHILDERS, Matthew, L.; LLINAS, Francesc Xavier Fradera; ELLIS, J. Michael; ESPOSITE, Sara; HONG, Qingmei; HUANG, Chunhui; KIM, Alexander, J.; LAMPE, John, W.; MACHACEK, Michelle, R.; MCMASTERS, Daniel, R.; OTTE, Ryan, D.; PARKER, Dann, L., Jr.; REUTERSHAN, Michael; SCIAMMETTA, Nunzio; SHAO, Pengcheng, P.; SLOMAN, David, L.; UJJAINWALLA, Feroze; WHITE, Catherine; WU, Zhicai; YU, Yang; ZHAO, Kake; GIBEAU, Craig; BIFTU, Tesfaye; BIJU, Purakkattle; CHEN, Lei; CLOSE, Joshua; FULLER, Peter, H.; HUANG, Xianhai; PARK, Min, K.; SIMOV, Vladimir; WITTER, David, J.; ZHANG, Hongjun; (297 pag.)WO2016/89797; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem