With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.301221-79-4,tert-Butyl 4-(2-bromoacetyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
The bromomethylketone prepared as described in Step C (1.48 g, 4.83 mmol) was combined with thioformamide (295 mg, 4.83 mmol) in 10 mL of THF. The reaction mixture was warmed to 60 ¡ãC and stirred for 4 days. The reaction mixture was then diluted with ethyl acetate and washed with water, then brine, dried over anhydrous MgS04, filtered, and concentrated. Purification by MPLC (silica, 60percent ethyl acetate/hexane) afforded 627 mg of thiazole PRODUCT. 1H NMR (400 MHz, CDC13) : 8 8.75 (d, J = 2.0 Hz, 1H), 6.93 (d, J = 2.4 Hz, 1H), 4.19 (br s, 2H), 2.96 (m, 1H), 2.84 (BR M, 2H), 2.03 (m, 2H), 1.62 (m, 2H), 1.44 (s, 9H)., 301221-79-4
As the paragraph descriping shows that 301221-79-4 is playing an increasingly important role.
Reference£º
Patent; MERCK & CO., INC.; WO2004/41279; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem