Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 13360-65-1, Name is 3-Ethyl-2,5-dimethylpyrazine, molecular formula is C8H12N2, belongs to piperidines compound. In a document, author is Cao, Xudong, introduce the new discover, Quality Control of 3-Ethyl-2,5-dimethylpyrazine.
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics
Herein, a novel series of multireceptor ligands was developed as polypharmacological antipsychotic agents using the designed multiple ligand approach between dopamine receptors and serotonin receptors. Among them, compound 47 possessed unique pharmacological features, exhibiting high affinities for D-2, D-3, 5-HT1A, 5-HT2A, and 5-HT6 receptors and low efficacy at the off-target receptors (5-HT2C, histamine H-1, and adrenergic alpha(1) receptor). Compound 47 showed dose-dependent inhibition of apomorphine- and MK-801-induced motor behavior, and the conditioned avoidance response with low cataleptic effect. Moreover, compound 47 resulted nonsignificantly serum prolactin levels and weight gain change compared with risperidone. Additionally, compound 47 possessed a favorable pharmacokinetic profile with oral bioavailability of 58.8% in rats. Furthermore, compound 47 displayed procognition properties in a novel object recognition task in rats. Taken together, compound 47 may constitute a novel class of atypical antipsychotic drugs for schizophrenia.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 13360-65-1. Quality Control of 3-Ethyl-2,5-dimethylpyrazine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem