With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29608-05-7,4-(Piperidin-1-ylmethyl)aniline,as a common compound, the synthetic route is as follows.
Example 84 (Production of Compound 84) To 3-benzyloxybenzoic acid (800 mg) dissolved in THF (10 ml) were added oxalyl chloride (397 mul) and one drop of DMF, and the resulting mixture was stirred at room temperature for one hour. After the reaction mixture was evaporated to remove the solvent, to the residue dissolved in THF (15 ml) were added dropwise at room temperature 1-(4-aminobenzyl)piperidine (733 mg) and triethylamine (589 mul). This reaction mixture was stirred at room temperature for 17 hours, was then mixed with water (100 ml) and was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated solution of sodium chloride, was dried with anhydrous sodium sulfate and was then evaporated under reduced pressure to remove the solvent. The resulting residue was recrystallized from ethyl acetate/hexane to obtain 3-benzyloxy-4′-(piperidinomethyl)benzanilide (compound 84) (1.06 g) as colorless crystals., 29608-05-7
The synthetic route of 29608-05-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6627651; (2003); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem