With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2905-56-8,1-Benzylpiperidine,as a common compound, the synthetic route is as follows.
In the reaction tube is sequentially added 1n (0.5 mmol, 88 mg), 2a (0.6 mmol, 90 mg), acetonitrile (3 ml), copper bromide (0.05 mmol, 11 mg) and di-tert-butyl peroxide (1 mmol, 183 mul), in air (1 atm) atmosphere at 60 C stirring reaction 24 h. Then add 10 ml saturated salt water quenching reaction, extracted with ethyl acetate (10 ml × 3), combined with the organic phase, dried with anhydrous sodium sulfate. Filtering, turns on lathe does, too separating by silica gel column (petroleum ether/ethyl acetate=5/1) to get the yellow solid product 3n (71 mg, 51%)., 2905-56-8
The synthetic route of 2905-56-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Henan Normal University; Fan Xuesen; Shi Xiaonan; Zhang Xinying; Chen Qian; (19 pag.)CN108516952; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem