With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.287953-54-2,Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
(1) To a solution of Compound 1 (1574 mg) in dichloromethane (10 mL) was added an aqueous solution of dimethylamine (50% aqueous solution, 2 mL) under ice-cooling, and then the mixture was stirred at room temperature for 2 hours. To the reaction mixture were added an aqueous solution of hydrochloric acid (0.5 mol/L) and chloroform, stirred, then the organic layer was separated, washed with saturated saline, dried, and then concentrated under reduced pressure to give Compound 2 (1.609 g) as a colorless viscous material. MS (APCI): m/z 327 [M+H] +
287953-54-2, The synthetic route of 287953-54-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; YAMAMOTO, Yasuo; SATO, Atsushi; MOROKUMA, Kenji; SHITAMA, Hiroaki; ADACHI, Takashi; MIYASHIRO, Masahiko; (260 pag.)EP3150578; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem