With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24686-78-0,1-Benzoylpiperidin-4-one,as a common compound, the synthetic route is as follows.
Step A Preparation of 1′-benzoyl-spiro[1,3-benzodithiole-2,4′-piperidine] 500 mgs (3.52 mmol) of 1,2-dimercaptobenzene and 610 mgs (3.00 mmol) of N-benzoyl-4-piperidone were stirred in CH2 Cl2 while anhydrous HCl gas was introduced Na2 SO4 (2 grams) was added and the mixture stirred 15 hours. The mixture was diluted with CH2 Cl2 filtered and washed with H2 O, and 10percent NaOH. The organics were dried (Na2 SO4) and concentrated to a solid (yield 740 mgs). ‘H NMR (CDCl3) delta:2.30 (bm, 4H); 3.5-4.0 (bd, 4H); 7.04 (m, 2H); 7.20 (m, 2H); 7.40 (m, 5H).
24686-78-0, As the paragraph descriping shows that 24686-78-0 is playing an increasingly important role.
Reference：
Patent; Merck & Co., Inc.; US5206240; (1993); A;,
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