With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24686-78-0,1-Benzoylpiperidin-4-one,as a common compound, the synthetic route is as follows.
(a) 1-Benzoyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro- pyridine. In a 1000-ml round-bottomed flask equipped with a Dean-Stark apparatus, a condenser, a calcium chloride guard tube, a magnetic stirrer and oil-bath heating, 94.7 g (0.466 mole) of 1-benzoyl-4-piperidinone, 200 ml of toluene and 52.5 g (0.74 mole) of pyrrolidine are introduced. The mixture is heated under reflux until the water has been completely removed (approximately 3 hours). The mixture is allowed to cool and is evaporated. An orange oil remains.
24686-78-0, As the paragraph descriping shows that 24686-78-0 is playing an increasingly important role.
Reference：
Patent; Synthelabo; US4661498; (1987); A;,
Piperidine – Wikipedia
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