With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24666-56-6,3-Aminopiperidine-2,6-dione hydrochloride,as a common compound, the synthetic route is as follows.,24666-56-6
3-nitrophthalic anhydride (I, 44.0 g, 0.23 mol), 3-amino-2,6-piperidinedione hydrochloride(II, 37.9 g, 0.23 mol) was dissolved in 600 mL of tetrahydrofuran (THF)Triethylamine (23.27 g, 0.23 mol) was then added dropwise to the system,The temperature of the control system was <20¡ãC . After the dropwise addition, the reaction was carried out for 30 min at room temperature, and the filter cake was filtered through THF (30 mL x 3) and dried in vacuo to give the intermediate 67.20 g in 91.0percent yield.
As the paragraph descriping shows that 24666-56-6 is playing an increasingly important role.
Reference£º
Patent; Shanghai Institute of Pharmaceutical Industry; China Institute of Pharmaceutical Industry; LI, JIAN QI; HUANG, DAO WEI; ZHOU, AI NAN; LIU, YU; ZHU, MIN YU; (9 pag.)CN103724323; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem