With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24666-56-6,3-Aminopiperidine-2,6-dione hydrochloride,as a common compound, the synthetic route is as follows.
[00409j Step 3: A mechanically stirred mixture of 4-bromo-2-bromomethyl-benzoic acid methyl ester (121 g, 390 mmol) and 3-amino-piperidine-2,6-dione hydrochloride (64.2 g, 390 mmol) in DMF (400 mL) was treated dropwise with triethylamine (98.5 g, 980 mmol) over75 minutes. After the addition was completed, the reaction mixture was stirred at room temperature overnight. The mixture was quenched sequentially with acetic acid (50 mL), water (2500 mL) and a 1:1 mixture of ethyl acetate and hexanes (600 mL). After stirring the mixture for 20 minutes, the solid was filtered, washed with water, and air dried overnight. The solid was stirred in acetic acid (200 mL) and refluxed for 2 hours. The mixture was cooled to room temperature and filtered. The solid was washed with additional acetic acid, hexanes, and air dried overnight to give 25.4 g of 3 -(5-bromo- 1 -oxo- 1 ,3-dihydro-isoindol-2-yl)-piperidine-2,6- dione as a grey solid, in 20% yield; 1H NMR (DMSO-d6) oe 1.97-2.04 (m, 1H), 2.32-2.46 (m, 1H), 2.56-2.63 (m, 1H), 2.85-2.97 (m, 1H), 4.34 (d, J = 17.7 Hz, 1H), 4.47 (d, J = 17.7 Hz, 1H),5.11 (dd,J= 13.2Hz,J5.1 Hz, 1H),7.67(d,J8.1 Hz, 1H),7.72(dd,J=8.1 Hz,J= 1.5Hz, 1H), 7.89 (d, J = 0.9 Hz, 1H), 11.00 (s, 1H).
24666-56-6, As the paragraph descriping shows that 24666-56-6 is playing an increasingly important role.
Reference£º
Patent; CELGENE CORPORATION; LOPEZ-GIRONA, Antonia; CATHERS, Brian, E.; LU, Gang; JACKSON, Pilgrim; HANDA, Hiroshi; (184 pag.)WO2016/57503; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem