With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.223632-64-2,1-(3-Chloro-4-fluorobenzoyl)piperidin-4-one,as a common compound, the synthetic route is as follows.
To a solution of 1-[(3-chloro-4-fluorophenyl) carbonyl] piperidin-4-one [Example 1, Step 2] (2 g, 7.8 mmol, 1.00 equiv) in dichloromethane (20 mL) was added sodium hydroxide (30.5% in H2O) (5.4 mL, 7.00 equiv), TBAC (108 mg, 0.38 mmol, 0.05 equiv) and 2-chloroacetonitrile (1.18 g, 15.6 mmol, 2.00 equiv) at 0 C. The reaction solution was stirred for 1 h at room temperature. The resulting solution was diluted with water (100 mL). The resulting solution was extracted with dichloromethane (3×100 mL). The organic layers were washed with brine (3×50 mL). The mixture was dried over anhydrous sodium sulfate and concentrated under vacuum to afford 1.1 g (48%) of 6-[(3-chloro-4-fluorophenyl)carbonyl]-1-oxa-6-azaspiro[2.5]octane-2-carbonitril as a brown solid. LC-MS: m/z=295[M+H]+., 223632-64-2
223632-64-2 1-(3-Chloro-4-fluorobenzoyl)piperidin-4-one 10611056, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Auspex Pharmaceuticals, Inc.; ZHANG, Chengzhi; (94 pag.)US2018/79742; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem